载银纳米粒子涂层的三种新型配合物对 A549 癌细胞的抗肿瘤活性。

Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles.

机构信息

Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.

Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland.

出版信息

Int J Mol Sci. 2022 Mar 10;23(6):2980. doi: 10.3390/ijms23062980.

A novel biologically active organic ligand L (N'-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal-ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25-800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging.

一种新型生物活性有机配体 L（N'-苄叉基吡嗪-2-甲酰腙）及其三种配位化合物已被合成并进行了结构描述。它们的物理化学和生物学性质已被深入研究。Cu(II)、Zn(II)和 Cd(II)配合物通过火焰原子吸收光谱法和元素分析进行了分析。根据傅里叶变换红外光谱和紫外可见近红外光谱研究了金属-配体配位方式。在 25-800°C 的温度范围内研究了所研究化合物的热行为。所有化合物在室温下稳定。配合物分几个阶段分解。磁性研究表明存在强烈的反铁磁相互作用。它们对 A549 肺癌细胞的细胞毒性活性已被研究，结果令人鼓舞。我们还研究了用银纳米粒子包覆研究配合物的生物学效应。使用扫描电子显微镜成像研究了表面的形态。