ELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, Italy.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Int J Mol Sci. 2022 Mar 15;23(6):3157. doi: 10.3390/ijms23063157.
We discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding of complex anatomy. We highlight the fundamental role of physical forces in cellular decisions, stressing the intriguing similarities in early morphogenesis, tissue regeneration, and oncogenic drift. Compelling evidence is presented, showing that biological patterns are strongly embedded in the vibrational nature of the physical energies that permeate the entire universe. We describe biological dynamics as informational processes at which physics and chemistry converge, with nanomechanical motions, and electromagnetic waves, including light, forming an ensemble of vibrations, acting as a sort of control software for molecular patterning. Biomolecular recognition is approached within the establishment of coherent synchronizations among signaling players, whose physical nature can be equated to oscillators tending to the coherent synchronization of their vibrational modes. Cytoskeletal elements are now emerging as senders and receivers of physical signals, "shaping" biological identity from the cellular to the tissue/organ levels. We finally discuss the perspective of exploiting the diffusive features of physical energies to afford in situ stem/somatic cell reprogramming, and tissue regeneration, without stem cell transplantation.
我们讨论了控制生物形态和功能开始的信号的复杂性的新观点，从基于超分子相互作用的纳米结构，到细胞/多细胞组织水平，再到复杂解剖结构的展开。我们强调了物理力在细胞决策中的基本作用，强调了早期形态发生、组织再生和致癌漂移之间有趣的相似之处。有强有力的证据表明，生物模式强烈地嵌入了弥漫在整个宇宙中的物理能量的振动性质中。我们将生物动力学描述为信息处理过程，物理学和化学在此汇聚，纳米力学运动和包括光在内的电磁波形成了一系列振动，充当分子模式形成的控制软件。生物分子识别是在信号转导因子之间建立相干同步的过程中进行的，其物理性质可以等同于倾向于相干同步其振动模式的振荡器。细胞骨架元件现在作为物理信号的发送者和接收者出现，从细胞到组织/器官水平“塑造”生物特性。最后，我们讨论了利用物理能量的扩散特性来实现原位干细胞/体干细胞重编程和组织再生，而无需干细胞移植的观点。
