Resnick L M, Müller F B, Laragh J H
Ann Intern Med. 1986 Nov;105(5):649-54. doi: 10.7326/0003-4819-105-5-649.
Circulating levels of the calcium-regulating hormones, calcitonin, calcitriol, and parathyroid hormone, were analyzed in relation to plasma renin activity in 10 persons with normal blood pressure and in 51 persons with essential hypertension. Calcitriol (p less than 0.008) and parathyroid hormone (p less than 0.01) levels were elevated in hypertensives with low renin activity, whereas calcitonin levels were higher in patients with high renin activity (p less than 0.008), compared with normotensive controls and other hypertensive patients. Continuous relationships were observed between calcitriol levels and plasma renin activity in all patients (r = -0.65, p less than 0.001) and between parathyroid hormone levels and urinary sodium excretion in hypertensive patients with low renin activity (r = -0.63, p less than 0.01). Together, these results support a linkage between calcium metabolism and renin-sodium factors in essential hypertension. Calcium-regulating hormones and the renin-aldosterone system may coordinately mediate the blood pressure effects of differing dietary calcium and sodium intakes at the cellular level by altering cellular handling of monovalent and divalent ions.
对10名血压正常者和51名原发性高血压患者，分析了钙调节激素（降钙素、骨化三醇和甲状旁腺激素）的循环水平与血浆肾素活性之间的关系。与血压正常对照者及其他高血压患者相比，肾素活性低的高血压患者骨化三醇水平升高（p<0.008），甲状旁腺激素水平升高（p<0.01），而肾素活性高的患者降钙素水平更高（p<0.008）。在所有患者中，骨化三醇水平与血浆肾素活性之间存在连续关系（r = -0.65，p<0.001），在肾素活性低的高血压患者中，甲状旁腺激素水平与尿钠排泄之间存在连续关系（r = -0.63，p<0.01）。这些结果共同支持原发性高血压中钙代谢与肾素-钠因子之间存在联系。钙调节激素和肾素-醛固酮系统可能通过改变细胞对单价和二价离子的处理，在细胞水平上协同介导不同饮食中钙和钠摄入量对血压的影响。
