Barsan Maria, Brata Anca Monica, Ismaiel Abdulrahman, Dumitrascu Dinu Iuliu, Badulescu Andrei-Vlad, Duse Traian Adrian, Dascalescu Stefana, Popa Stefan Lucian, Grad Simona, Muresan Lucian, Maerescu Carmen Maria, Cismaru Gabriel, Brata Vlad Dumitru
Department of Occupational Health, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Faculty of Environmental Protection, University of Oradea, 410048 Oradea, Romania.
Biomedicines. 2022 May 26;10(6):1239. doi: 10.3390/biomedicines10061239.
The global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the transient outward current and the ultrarapid delayed rectifier K+ current densities, activated through the nuclear vitamin D receptor and Akt pathway. A significant number of studies have correlated vitamin D deficiency with an increased risk of developing cardiac arrhythmias and sudden cardiac death. For this reason, the purpose of this review is to analyze the relation between vitamin D deficiency and the pathogenesis of cardiac arrhythmias. Atrial fibrillation, increased QT interval, and QT dispersion were the most common findings associated with vitamin D deficiency. Due to the heterogeneity among existing studies, further research is necessary to confirm the existing data and to analyze its relationship with other types of arrhythmias.
全球维生素D缺乏症的患病率超过20%，主要原因包括摄入不足、吸收减少、代谢异常或对其作用产生抵抗。血清维生素D水平似乎会影响心血管风险，其涉及的机制与通过核维生素D受体和Akt途径激活的瞬时外向电流和超快速延迟整流钾电流密度有关。大量研究已将维生素D缺乏与发生心律失常和心源性猝死的风险增加相关联。因此，本综述的目的是分析维生素D缺乏与心律失常发病机制之间的关系。心房颤动、QT间期延长和QT离散度增加是与维生素D缺乏相关的最常见表现。由于现有研究之间存在异质性，有必要进行进一步研究以证实现有数据，并分析其与其他类型心律失常的关系。
