Grazioli Elisa, Tranchita Eliana, Marrone Giulia, Urciuoli Silvia, Di Lauro Manuela, Cerulli Claudia, Piacentini Nicolò, Murri Arianna, Celotto Roberto, Romani Annalisa, Parisi Attilio, Di Daniele Nicola, Noce Annalisa
Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.
Department of Experimental and Clinical Medicine, "Magna Graecia" University, 88100 Catanzaro, Italy.
Int J Environ Res Public Health. 2022 Mar 10;19(6):3281. doi: 10.3390/ijerph19063281.
Chronic kidney disease (CKD) represents a public health problem because it is characterized by several comorbidities, including uremic sarcopenia (US), and a poor quality of life. Currently, there are no standardized treatments available to counteract the onset of US but only some possible therapeutic approaches to slow its progression. The aim of this pilot study is to collect descriptive data in order to design a clinical trial based on the power analysis and simple size. The purpose of this pilot study was to evaluate the possible beneficial action induced by the functional anti-inflammatory and antioxidant bars in combination with the adapted physical activity (APA), on the onset and progression of US and other related-CKD comorbidities. We enrolled 21 CKD patients under conservative therapy, divided into four groups: (A) the physical exercise program (PEP), three times a week, in combination with the daily consumption of the two functional bars group; (B) the PEP group; (C) the daily consumption of the two functional bars group; (D) the control group. The duration of the study protocol was 12 weeks. We observed an improvement trend of body composition, blood pressure levels, lipid metabolism, and functional test in A and B groups. These preliminary data would seem to confirm the effectiveness of APA and to demonstrate the additive role of the natural bioactive compound's assumption in countering US and other CKD comorbidities.
慢性肾脏病（CKD）是一个公共卫生问题，因为它具有多种合并症，包括尿毒症性肌肉减少症（US），且生活质量较差。目前，尚无标准化治疗方法可对抗US的发生，仅有一些可能的治疗方法来减缓其进展。这项初步研究的目的是收集描述性数据，以便根据功效分析和样本量设计一项临床试验。这项初步研究的目的是评估功能性抗炎和抗氧化棒与适应性体育活动（APA）联合使用对US及其他相关CKD合并症的发生和进展可能产生的有益作用。我们招募了21名接受保守治疗的CKD患者，分为四组：（A）每周进行三次体育锻炼计划（PEP），并每日食用两根功能性棒的组；（B）PEP组；（C）每日食用两根功能性棒的组；（D）对照组。研究方案持续时间为12周。我们观察到A组和B组在身体成分、血压水平、脂质代谢和功能测试方面有改善趋势。这些初步数据似乎证实了APA的有效性，并证明了天然生物活性化合物摄入在对抗US及其他CKD合并症中的累加作用。
