Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, and.
Environ Health Perspect. 2013 Nov-Dec;121(11-12):1372-7. doi: 10.1289/ehp.1306480. Epub 2013 Aug 16.
Few studies have evaluated predictors of childhood exposure to organochlorine pesticides (OCPs), a class of lipophilic persistent chemicals.
Our goal was to identify predictors of serum OCP concentrations-hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p´-DDE)-among boys in Chapaevsk, Russia.
Between 2003 and 2005, 499 boys 8-9 years of age were recruited in a prospective cohort. The initial study visit included a physical examination; blood collection; health, lifestyle, and food-frequency questionnaires; and determination of residential distance from a local factory complex that produced HCB and β-HCH. Fasting serum samples were analyzed for OCPs at the U.S. Centers for Disease Control and Prevention. General linear regression models were used to identify predictors of the boys' serum HCB, β-HCH, and p,p´-DDE concentrations.
Among 355 boys with OCP measurements, median serum HCB, β-HCH, and p,p´-DDE concentrations were 158, 167, and 284 ng/g lipid, respectively. Lower body mass index, longer breastfeeding duration, and local dairy consumption were associated with higher concentrations of OCPs. Boys who lived < 2 km from the factory complex had 64% (95% CI: 37, 96) and 57% (95% CI: 32, 87) higher mean HCB and β-HCH concentrations, respectively, than boys who lived ≥ 5 km away. Living > 3 years in Chapaevsk predicted higher β-HCH concentrations, and having parents who lacked a high school education predicted higher p,p´-DDE concentrations.
Among this cohort of prepubertal Russian boys, predictors of serum OCPs included consumption of local dairy products, longer local residence, and residential proximity to the local factory complex.
很少有研究评估儿童接触有机氯农药 (OCPs) 的预测因素，OCPs 是一类亲脂性持久性化学物质。
我们的目标是确定俄罗斯查帕耶夫斯克男孩血清 OCP 浓度（六氯苯 (HCB)、β-六氯环己烷 (β-HCH) 和 p,p-二氯二苯二氯乙烯 (p,p´-DDE）的预测因素。
2003 年至 2005 年间，在一个前瞻性队列中招募了 499 名 8-9 岁的男孩。首次研究访问包括体检、血液采集、健康、生活方式和食物频率问卷以及确定距离当地生产 HCB 和 β-HCH 的工厂综合体的居住距离。在美国疾病控制与预防中心对空腹血清样本进行 OCP 分析。使用线性回归模型确定男孩血清 HCB、β-HCH 和 p,p´-DDE 浓度的预测因素。
在 355 名有 OCP 测量值的男孩中，血清 HCB、β-HCH 和 p,p´-DDE 浓度的中位数分别为 158、167 和 284ng/g 脂质。较低的体重指数、较长的母乳喂养时间和当地乳制品的消费与较高的 OCP 浓度有关。居住在距离工厂综合体<2 公里的男孩的 HCB 和 β-HCH 浓度分别比居住在 5 公里以上的男孩高 64%（95%CI：37，96）和 57%（95%CI：32，87）。在查帕耶夫斯克居住>3 年预测β-HCH 浓度较高，父母未接受过高中教育预测 p,p´-DDE 浓度较高。
在这个俄罗斯青春期前男孩队列中，血清 OCP 的预测因素包括当地乳制品的消费、较长的当地居住时间和与当地工厂综合体的居住距离。
