Bodey G P, Alvarez M E, Jones P G, Rolston K V, Steelhammer L, Fainstein V
Antimicrob Agents Chemother. 1986 Aug;30(2):211-4. doi: 10.1128/AAC.30.2.211.
Imipenem-cilastatin was used to treat 79 febrile episodes in 71 cancer patients, most of whom had neutropenia. The overall response rate was 67%, and 76% of the 45 documented infections responded. The response rates for septicemias and pneumonias were 79 and 62%, respectively. Only 1 of the 17 infections caused by gram-negative bacilli failed to respond to this therapy. The most common side effects were skin rash, nausea, and diarrhea. Eight superinfections were detected during therapy.
亚胺培南-西司他丁用于治疗71例癌症患者的79次发热发作，其中大多数患者有中性粒细胞减少症。总体有效率为67%，45例有记录的感染中有76%有反应。败血症和肺炎的有效率分别为79%和62%。17例由革兰氏阴性杆菌引起的感染中只有1例对该治疗无反应。最常见的副作用是皮疹、恶心和腹泻。治疗期间检测到8例二重感染。
