亚胺培南、阿米卡星、甲氧苄啶-磺胺甲恶唑和米诺环素治疗实验性脑诺卡菌病
Therapy of experimental cerebral nocardiosis with imipenem, amikacin, trimethoprim-sulfamethoxazole, and minocycline.
作者信息
Gombert M E, Aulicino T M, duBouchet L, Silverman G E, Sheinbaum W M
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):270-3. doi: 10.1128/AAC.30.2.270.
Abstract
A mouse model of cerebral nocardiosis was used to determine relative antibiotic efficacy by reducing bacterial colony counts per gram of brain tissue. The antimicrobial agents employed were demonstrated in vitro to be inhibitory to most strains of Nocardia asteroides at very low concentrations. The agents used in this study were imipenem-cilastatin, amikacin, trimethoprim-sulfamethoxazole, and minocycline. Antibiotics were administered every 4 h for 72 h before animal sacrifice. Bacterial colony counts were assayed at various time points before the completion of therapy. Imipenem-cilastatin and amikacin were the most effective agents tested. Trimethoprim-sulfamethoxazole was less effective than imipenem and amikacin but more effective than minocycline. Minocycline did not eradicate intracerebral organisms and was similar to saline (control) in its effects.
摘要
通过减少每克脑组织中的细菌菌落数，使用脑诺卡菌病小鼠模型来确定相关抗生素的疗效。所使用的抗菌剂在体外被证明在非常低的浓度下对大多数星形诺卡菌菌株具有抑制作用。本研究中使用的药物有亚胺培南-西司他丁、阿米卡星、甲氧苄啶-磺胺甲恶唑和米诺环素。在处死动物前，每4小时给予抗生素，共72小时。在治疗结束前的不同时间点测定细菌菌落数。亚胺培南-西司他丁和阿米卡星是测试中最有效的药物。甲氧苄啶-磺胺甲恶唑的效果不如亚胺培南和阿米卡星，但比米诺环素更有效。米诺环素不能根除脑内病原体，其效果与生理盐水（对照）相似。
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本文引用的文献
1
Nocardia asteroides; studies of its pathogenicity and drug sensitivities.星形诺卡菌；其致病性和药敏性研究
J Lab Clin Med. 1951 May;37(5):713-20.
2
Nocardiosis of the central nervous system.中枢神经系统诺卡菌病
J Neurosurg. 1954 May;11(3):226-33. doi: 10.3171/jns.1954.11.3.0226.
3
Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin.星形诺卡菌对多种抗生素的敏感性，包括新型β-内酰胺类、甲氧苄啶-磺胺甲恶唑、阿米卡星和N-甲酰亚胺硫霉素。
Antimicrob Agents Chemother. 1982 Jun;21(6):1011-2. doi: 10.1128/AAC.21.6.1011.
4
Response of CBA/N x DBA2/F1 mice to Nocardia asteroides.CBA/N×DBA2/F1小鼠对星形诺卡菌的反应
Infect Immun. 1982 Jan;35(1):111-6. doi: 10.1128/iai.35.1.111-116.1982.
5
Nocardial infections in the immunocompromised host: A detailed study in a defined population.免疫功能低下宿主中的诺卡菌感染：对特定人群的详细研究。
Rev Infect Dis. 1981 May-Jun;3(3):492-507. doi: 10.1093/clinids/3.3.492.
6
Human nocardiosis. A clinical review with selected case reports.人类诺卡菌病。附病例报告的临床综述。
Arch Intern Med. 1980 Jun;140(6):818-26. doi: 10.1001/archinte.140.6.818.
7
Use of trimethoprim-sulfamethoxazole for treatment of infections due to Nocardia.使用甲氧苄啶-磺胺甲恶唑治疗诺卡菌属感染。
Rev Infect Dis. 1982 Mar-Apr;4(2):315-25. doi: 10.1093/clinids/4.2.315.
8
Trimethoprim/sulfamethoxazole-resistant Nocardia asteroides causing multiple hepatic abscesses. Successful treatment with ampicillin, amikacin, and limited computed tomography-guided needle aspiration.耐甲氧苄啶/磺胺甲恶唑的星形诺卡菌引起多发性肝脓肿。氨苄西林、阿米卡星及有限的计算机断层扫描引导下经皮穿刺抽吸引流治疗成功。
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9
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