亚胺培南与阿米卡星联合其他抗生素对星形诺卡菌的协同作用。
Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides.
作者信息
Gombert M E, Aulicino T M
出版信息
Antimicrob Agents Chemother. 1983 Nov;24(5):810-1. doi: 10.1128/AAC.24.5.810.
Abstract
The in vitro activities of imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK0787) and amikacin in combination with cefotaxime, trimethoprim-sulfamethoxazole, and each other were tested against 26 Nocardia asteroides strains. The agar dilution method was used for all tests. Synergy was present in 80% of tests with imipenem-trimethoprim-sulfamethoxazole, in 92% of tests with imipenem-cefotaxime, and in 83% of tests with amikacin-trimethoprim-sulfamethoxazole. Indifference was found on rare occasions, and no antagonism was seen.
摘要
针对26株星形诺卡菌，测试了亚胺培南（原称亚胺培米、N-甲酰亚胺硫霉素或MK0787）及阿米卡星分别与头孢噻肟、甲氧苄啶-磺胺甲恶唑联合使用时的体外活性，以及它们之间联合使用时的体外活性。所有测试均采用琼脂稀释法。在80%的亚胺培南-甲氧苄啶-磺胺甲恶唑联合测试中、92%的亚胺培南-头孢噻肟联合测试中以及83%的阿米卡星-甲氧苄啶-磺胺甲恶唑联合测试中存在协同作用。在极少数情况下发现为无关作用，未观察到拮抗作用。
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