Cremades M J, Menéndez R, Santos M, Gobernado M
Servicio de Neumología, Hospital Universitario La Fe, Valencia, Espania.
Respiration. 1998;65(3):211-3. doi: 10.1159/000029264.
A rare case of pulmonary nocardiosis was presented in a nonimmunocompromised patient who had chronic airway obstruction and bronchiectasis without corticoid treatment. The microbial diagnosis was established after isolating Nocardia in bronchial aspirate and sputum samples. An in vitro study showed sensitivity only to imipenem, netilmicine, amikacin and ofloxacin. The evolution was chronic, with multiple clinical recurrences in spite of prolonged antibiotic treatment. Finally, the eradication of Nocardia was achieved with the combination of imipenem and amikacin.
本文报告了一例罕见的肺诺卡菌病病例，患者无免疫功能低下，有慢性气道阻塞和支气管扩张，未接受皮质激素治疗。在支气管吸出物和痰液样本中分离出诺卡菌后，做出了微生物学诊断。一项体外研究表明，该菌仅对亚胺培南、奈替米星、阿米卡星和氧氟沙星敏感。尽管进行了长期抗生素治疗，但病情呈慢性，多次临床复发。最后，联合使用亚胺培南和阿米卡星实现了诺卡菌的根除。
