Solana-Gracia Ruth, Modesto I Alapont Vicent, Bueso-Inchausti Leticia, Luna-Arana María, Möller-Díez Ariadna, Medina Alberto, Pérez-Moneo Begoña
Department of Paediatrics, Hospital Universitario Infanta Leonor y Hospital Virgen de la Torre, 28031 Madrid, Spain.
Paediatric Intensive Care Unit, Hospital Universitario La Fe, 46026 Valencia, Spain.
J Clin Med. 2022 Mar 15;11(6):1622. doi: 10.3390/jcm11061622.
There is limited evidence of the potential benefits of the use of high-flow nasal cannula (HFNC) for the management of bronchiolitis in the ward. Our aim is to describe the ventilation trends for bronchiolitis in our hospital along with the introduction of an HFNC ward protocol and to determine the need for respiratory support escalation and transfer to an intensive care unit (ICU). A retrospective analytical observational study of children < 12 months old requiring admission for a first RSV bronchiolitis episode in a single centre from January 2009 to December 2018. The sample was divided into four groups according to the type of respiratory support that would ensure the clinical stability of the infants on admission. A total of 502 infants were recruited. The total number and percentage of patients admitted in the ward grew progressively over time. Simultaneously, there was an increase in HFNC and, paradoxically, an increase in ICU transfers. The risk of failure was higher for those who required HFNC or CPAP for clinical stabilisation in the first 12 h after admission. Moreover, the risk of failure was also higher in children with standard oxygen therapy promptly escalated to HFNC, especially if they had atelectasis/viral pneumonia, coinfections or a history of prematurity. Despite the limitations of a retrospective analysis, our study reflects usual clinical practice and no correlation was found between the usage of HFNC and a shorter length of hospital stay or less time spent on oxygen therapy.
在病房中,使用高流量鼻导管(HFNC)治疗细支气管炎的潜在益处证据有限。我们的目的是描述我院细支气管炎的通气趋势,同时引入HFNC病房方案,并确定呼吸支持升级及转入重症监护病房(ICU)的必要性。对2009年1月至2018年12月在单一中心因首次呼吸道合胞病毒(RSV)细支气管炎发作而入院的12个月以下儿童进行回顾性分析观察研究。根据能确保婴儿入院时临床稳定的呼吸支持类型,将样本分为四组。共招募了502名婴儿。随着时间的推移,病房收治的患者总数及百分比逐渐增加。与此同时,HFNC使用量增加,而且矛盾的是,转入ICU的人数也增加了。入院后最初12小时内需要HFNC或持续气道正压通气(CPAP)来实现临床稳定的患者失败风险更高。此外,标准氧疗迅速升级为HFNC的儿童失败风险也更高,尤其是那些患有肺不张/病毒性肺炎、合并感染或有早产史的儿童。尽管回顾性分析存在局限性,但我们的研究反映了常规临床实践,且未发现HFNC的使用与缩短住院时间或减少氧疗时间之间存在关联。