Tong Guang, Wu Jinlin, Chen Zerui, Zhuang Donglin, Zhao Shuang, Liu Yaorong, Yang Yongchao, Liang Zhichao, Fan Ruixin, Sun Zhongchan, Sun Tucheng
Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Department of Cardiovascular Surgery, Department of Structural Heart Disease, National Center for Cardiovascular Disease, China and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
J Clin Med. 2022 Mar 18;11(6):1693. doi: 10.3390/jcm11061693.
Background: Coronary malperfusion (CM) secondary to acute type A aortic dissection (ATAAD) is considered rare but has a high mortality rate. This study examined the incidence, management, and outcomes of patients with CM secondary to ATAAD and proposes a modified Neri classification. Methods: Between 2015 and 2020, out of 1018 patients who underwent surgical repair for ATAAD, 137 presented with CM, including 68 (49.6%), 43 (31.3%), and 15 (10.9%) with Neri types A, B, and C, respectively, and 11 (8.0%) with coronary orifice intimal tear (COIT), which we consider a novel category. Results: The occurrence rate of CM was 13.4%. CM was associated with higher in-hospital mortality (18.2% vs. 7.8%, p < 0.001). For Neri type A (98.5%) and most type B lesions (72.1%), coronary repair was adequate. Coronary artery bypass grafting (CABG) was necessary for type B patients unsuited for repair (23.2%) and for all type C patients (100%). Repair of COIT was possible (45.5%). The in-hospital mortality rates differed significantly among the four lesion groups (p = 0.006). Conclusions: The occurrence of CM secondary to ATAAD may be more frequent than previously reported. Surgical management based on lesion classification achieved acceptable outcomes. Repair was adequate for Neri type A and most type B lesions. Other type B and type C lesions could be treated by CABG. Coronary orifice intimal tear is a unique set of lesions, for which orifice repair was also possible.
急性A型主动脉夹层(ATAAD)继发的冠状动脉灌注不良(CM)虽被认为罕见,但死亡率很高。本研究调查了ATAAD继发CM患者的发病率、治疗方法及预后,并提出了改良的内里分类法。方法:2015年至2020年间,在1018例行ATAAD手术修复的患者中,137例出现CM,其中内里A型、B型和C型分别有68例(49.6%)、43例(31.3%)和15例(10.9%),11例(8.0%)出现冠状动脉开口内膜撕裂(COIT),我们将其视为一种新类型。结果:CM的发生率为13.4%。CM与较高的院内死亡率相关(18.2%对7.8%,p<0.001)。对于内里A型(98.5%)和大多数B型病变(72.1%),冠状动脉修复是充分的。对于不适合修复的B型患者(23.2%)和所有C型患者(100%),需要进行冠状动脉旁路移植术(CABG)。COIT修复是可行的(45.5%)。四个病变组的院内死亡率差异有统计学意义(p = 0.006)。结论:ATAAD继发CM的发生率可能比先前报道的更高。基于病变分类的手术治疗取得了可接受的结果。内里A型和大多数B型病变修复充分。其他B型和C型病变可通过CABG治疗。冠状动脉开口内膜撕裂是一组独特的病变,其开口修复也是可行的。