Hong Rui, Sun Hongyu, Li Dujuan, Yang Weihuang, Fan Kai, Liu Chaoran, Dong Linxi, Wang Gaofeng
Ministry of Education Engineering Research Center of Smart Microsensors and Microsystems, Hangzhou Dianzi University, Hangzhou 310018, China.
School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China.
Life (Basel). 2022 Feb 25;12(3):342. doi: 10.3390/life12030342.
Breast cancer has the highest cancer incidence rate in women. Early screening of breast cancer can effectively improve the treatment effect of patients. However, the main diagnostic techniques available for the detection of breast cancer require the corresponding equipment, professional practitioners, and expert analysis, and the detection cost is high. Tumor markers are a kind of active substance that can indicate the existence and growth of the tumor. The detection of tumor markers can effectively assist the diagnosis and treatment of breast cancer. The conventional detection methods of tumor markers have some shortcomings, such as insufficient sensitivity, expensive equipment, and complicated operations. Compared with these methods, biosensors have the advantages of high sensitivity, simple operation, low equipment cost, and can quantitatively detect all kinds of tumor markers. This review summarizes the biosensors (2013-2021) for the detection of breast cancer biomarkers. Firstly, the various reported tumor markers of breast cancer are introduced. Then, the development of biosensors designed for the sensitive, stable, and selective recognition of breast cancer biomarkers was systematically discussed, with special attention to the main clinical biomarkers, such as human epidermal growth factor receptor-2 (HER2) and estrogen receptor (ER). Finally, the opportunities and challenges of developing efficient biosensors in breast cancer diagnosis and treatment are discussed.
乳腺癌在女性中的癌症发病率最高。乳腺癌的早期筛查可以有效提高患者的治疗效果。然而，现有的用于检测乳腺癌的主要诊断技术需要相应的设备、专业从业者和专家分析，且检测成本高昂。肿瘤标志物是一类能够指示肿瘤存在和生长的活性物质。肿瘤标志物的检测可以有效辅助乳腺癌的诊断和治疗。传统的肿瘤标志物检测方法存在一些缺点，如灵敏度不足、设备昂贵、操作复杂等。与这些方法相比，生物传感器具有灵敏度高、操作简单、设备成本低等优点，并且能够定量检测各种肿瘤标志物。本综述总结了2013年至2021年间用于检测乳腺癌生物标志物的生物传感器。首先，介绍了各种已报道的乳腺癌肿瘤标志物。然后，系统地讨论了为灵敏、稳定和选择性识别乳腺癌生物标志物而设计的生物传感器的发展情况，特别关注了主要的临床生物标志物，如人表皮生长因子受体2（HER2）和雌激素受体（ER）。最后，讨论了开发高效生物传感器在乳腺癌诊断和治疗中的机遇与挑战。
