Department of Electronic Science, Jogesh Chandra Chaudhuri College, Kolkata 700033, India.
Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Biomolecules. 2023 Jun 22;13(7):1024. doi: 10.3390/biom13071024.
An essential aspect of successful cancer diagnosis is the identification of malignant tumors during the early stages of development, as this can significantly diminish patient mortality rates and increase their chances of survival. This task is facilitated by cancer biomarkers, which play a crucial role in determining the stage of cancer cells, monitoring their growth, and evaluating the success of treatment. However, conventional cancer detection methods involve several intricate steps, such as time-consuming nucleic acid amplification, target detection, and a complex treatment process that may not be appropriate for rapid screening. Biosensors are emerging as promising diagnostic tools for detecting cancer, and carbon nanotube (CNT)- and graphene-based transistor biosensors have shown great potential due to their unique electrical and mechanical properties. These biosensors have high sensitivity and selectivity, allowing for the rapid detection of cancer biomarkers at low concentrations. This review article discusses recent advances in the development of CNT- and graphene-based transistor biosensors for cancer detection.
成功诊断癌症的一个重要方面是在早期阶段识别恶性肿瘤，因为这可以显著降低患者的死亡率并提高其生存率。癌症生物标志物在确定癌细胞的阶段、监测其生长以及评估治疗效果方面发挥着至关重要的作用，有助于实现这一目标。然而，传统的癌症检测方法涉及多个复杂的步骤，例如耗时的核酸扩增、靶标检测以及可能不适合快速筛选的复杂治疗过程。生物传感器作为癌症检测的有前途的诊断工具正在兴起，基于碳纳米管（CNT）和石墨烯的晶体管生物传感器由于其独特的电学和力学性质显示出巨大的潜力。这些生物传感器具有高灵敏度和选择性，能够在低浓度下快速检测癌症生物标志物。本文综述了 CNT 和石墨烯基晶体管生物传感器在癌症检测方面的最新进展。
