Daks Alexandra, Vasileva Elena, Fedorova Olga, Shuvalov Oleg, Barlev Nickolai A
Institute of Cytology RAS, 194064 St. Petersburg, Russia.
Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA.
Life (Basel). 2022 Mar 2;12(3):362. doi: 10.3390/life12030362.
Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.
赖氨酸特异性甲基转移酶7（KMT7），即SET7/9，也被称为Set7、Set9或SetD7，或者KMT5，是在20年前被发现的，但其生物学作用仍然相当神秘。在这篇综述中，我们分析了SET7/9酶活性和底物特异性的特点及其生物学重要性，主要聚焦于其两个已被充分表征的生物学功能：细胞增殖和应激反应。
