Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
J Am Acad Dermatol. 2020 Nov;83(5):1298-1303. doi: 10.1016/j.jaad.2020.07.006. Epub 2020 Jul 9.
Platelet-rich plasma (PRP) shows promise as an androgenetic alopecia (AGA) treatment.
To conduct a randomized placebo-controlled split-scalp study to investigate the effects of PRP on hair regrowth and thickness.
Two 7.6-cm × 7.6-cm squares were tattooed on the scalps of 35 study participants with AGA. Areas were randomly assigned to intradermal injection with PRP or saline. Participants received 3 monthly treatment sessions with evaluation 3 months after the final treatment.
Hair density in the PRP-treated area was significantly increased compared with baseline at all visits. At the final assessment, hair density in PRP-treated areas increased from 151 ± 39.82 hairs/cm at baseline to 170.96 ± 37.14 hairs/cm, a mean increase of approximately 20 hairs/cm (P < .05). However, hair density in placebo-treated areas also increased from 151.04 ± 41.99 hairs/cm to 166.72 ± 37.13 hairs/cm (P < .05). There was no significant difference in hair density change between the 2 groups (P > .05). No serious adverse events were reported.
Possible PRP diffusion due to split-scalp study design as well as microinjections causing microinjury to both sides.
PRP may have benefit in increasing hair density.
富血小板血浆（PRP）在雄激素性脱发（AGA）治疗中显示出潜力。
进行一项随机安慰剂对照的头皮分割研究，以调查 PRP 对头发生长和厚度的影响。
在 35 名 AGA 研究参与者的头皮上纹上两个 7.6cm×7.6cm 的正方形。区域被随机分配接受 PRP 或生理盐水的皮内注射。参与者接受了 3 个月的每月治疗，并在最后一次治疗后 3 个月进行评估。
与基线相比，PRP 治疗区域的毛发密度在所有访视中均显著增加。在最终评估时，PRP 治疗区域的毛发密度从基线时的 151±39.82 根/cm 增加到 170.96±37.14 根/cm，平均增加约 20 根/cm（P<.05）。然而，安慰剂治疗区域的毛发密度也从 151.04±41.99 根/cm 增加到 166.72±37.13 根/cm（P<.05）。两组之间的毛发密度变化没有显著差异（P>.05）。未报告严重不良事件。
由于头皮分割研究设计以及两侧微注射造成微损伤，可能存在 PRP 扩散。
PRP 可能有益于增加毛发密度。
