Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Amity Institute of Pharmacy, Amity University, Noida, India.
Curr Pharm Des. 2022;28(26):2140-2149. doi: 10.2174/1381612828666220324124720.
The advanced era has invited a plethora of chronic and autoimmune infirmities unmistakably dominated by rheumatoid arthritis, occurring because of equivocal causes, including ecological factors, genetic variations, etc. Unfortunately, it is winning pretty much in every stratum of the society in the undefined age group of the population. Engineered drugs are accessible for the treatment; however, they do experience adverse effects as the treatment requires a prolonged duration worsened by noncompliance. To overwhelm it, certain pharmacological and molecular pathways are explored in the wake of Chinese herbs that prompted the prevention of this deteriorating autoimmune disease. The alcoholic extracts and decoctions are procured from Chinese herbs, such as Paeonia lactiflora, Glycyrrhiza uralensis, Tripterygium wilfordii, etc., which have been proved to manifest constructive pharmacological actions. The activities that were exhibited by extracts are significantly innocuous, non-toxic, and potent to fix the affliction in contrast with the chemosynthetic drugs. Therefore, these Chinese herbs bring forth potent anti-inflammatory, immune-suppressing, anti-nociceptive, anti-neovascularizing, free radical scavenging activities, and various other benefits to withstand several pathological events that usually endure infirmity. It can be abridged that Chinese herbs possess assorted and selective therapeutic properties with profound safety and viability to treat this rheumatic disorder. Thus, this review aims to shed light on naturally originated treatment that is pertinent to providing invulnerable therapy exonerating from adverse effects by restraining joint deformities, production of auto-antibodies, and inflammation.
先进的时代带来了大量的慢性和自身免疫性疾病，其中类风湿关节炎尤为明显，其发生原因不明，包括生态因素、遗传变异等。不幸的是，它在社会的各个阶层、未定义的年龄组中都很普遍。有治疗用的药物，但由于治疗需要长期服用且患者不遵医嘱，这些药物会产生不良反应。为了克服这一问题，人们探索了某些药理学和分子途径，包括中草药，以预防这种不断恶化的自身免疫性疾病。中草药的酒精提取物和汤剂，如白芍、甘草、雷公藤等，已被证明具有积极的药理作用。这些提取物的活性无毒且有效，与化学合成药物相比，能有效治疗疾病。因此，这些中草药具有强大的抗炎、免疫抑制、镇痛、抗新生血管生成、清除自由基等多种功效，能抵抗多种通常导致疾病的病理事件。可以说，中草药具有多种选择性的治疗特性，安全性高、疗效好，可治疗风湿性疾病，避免不良反应引起的关节畸形、自身抗体产生和炎症。因此，本综述旨在阐明源于天然的治疗方法，为类风湿关节炎患者提供免疫治疗，避免不良反应，抑制关节畸形、自身抗体产生和炎症。
