雷公藤治疗类风湿关节炎抑制血管生成作用的研究进展
Tripterygium wilfordii Inhibiting Angiogenesis for Rheumatoid Arthritis Treatment.
机构信息
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300020, China.
Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300020, China.
出版信息
J Natl Med Assoc. 2017;109(2):142-148. doi: 10.1016/j.jnma.2017.02.007. Epub 2017 Mar 24.
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a serious pre-vascular inflammatory phase, followed by significant increase in vessel growth. Inhibition of angiogenesis is a novel therapeutic strategy against RA. The Chinese herbal remedy Tripterygium wilfordii, Hook. f. (TwHf) has been reported to be therapeutically efficacious in the treatment of RA. Recent studies have revealed that treatment with TwHf extracts inhibit angiogenesis of RA, thereby elaborately attenuation RA symptom. This review mainly addresses the anti-angiogenesis effect of TwHf in treatment of RA.
类风湿关节炎（RA）是一种慢性炎症性疾病，存在严重的血管前炎症阶段，随后血管生长显著增加。抑制血管生成是治疗 RA 的一种新的治疗策略。中药雷公藤（TwHf）已被报道在治疗 RA 方面具有治疗效果。最近的研究表明，TwHf 提取物治疗可抑制 RA 的血管生成，从而精细地减轻 RA 症状。本综述主要介绍了 TwHf 在治疗 RA 中的抗血管生成作用。
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