Li Jian-Ming, Jiang Quan, Tang Xiao-Po, Yang Hui, Zhou Zhi-Qiang
Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.
Zhongguo Zhong Yao Za Zhi. 2019 Aug;44(16):3384-3390. doi: 10.19540/j.cnki.cjcmm.20190103.001.
Rheumatoid arthritis( RA) is an autoimmune disease characterized by chronic and aggressive polyarthritis. The innate immunity mechanism plays a key role in the pathogenesis of RA. Tripterygium wilfordii and its extracts have regulatory effects on innate immune cells including macrophages,dendritic cells,neutrophils,mast cells,NK cells,NKT cells,etc.,as well as a variety of innate immune molecules including cytokines,adhesion molecules,patterns recognition receptor( PRR) and the complement molecules,showing a regulatory effect in the pathogenesis of RA innate immunity. In this paper,the recent domestic and foreign researches on the pathogenesis of RA with innate immunity involved were reviewed and the research status of T. wilfordii and its extracts on the regulation of innate immunity involved in RA was summarized.
类风湿关节炎（RA）是一种以慢性侵袭性多关节炎为特征的自身免疫性疾病。固有免疫机制在RA发病机制中起关键作用。雷公藤及其提取物对包括巨噬细胞、树突状细胞、中性粒细胞、肥大细胞、自然杀伤细胞、自然杀伤T细胞等在内的固有免疫细胞以及包括细胞因子、黏附分子、模式识别受体（PRR）和补体分子等多种固有免疫分子具有调节作用，在RA固有免疫发病机制中表现出调节效应。本文综述了近年来国内外有关RA发病机制涉及固有免疫的研究，并总结了雷公藤及其提取物对RA固有免疫调节的研究现状。
