Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
Protein Research Center, Shahid Beheshti University, Tehran, Iran.
Curr Drug Deliv. 2022;19(10):1001-1011. doi: 10.2174/1567201819666220324092933.
Lipid nanocarriers have great potential for the encapsulation and delivery of numerous bioactive compounds. They have demonstrated significant benefits over traditional disease management and conventional therapy. The benefits associated with the particular properties of lipid nanocarriers include site-specific drug deposition, improved pharmacokinetics and pharmacodynamics, enhanced internalization and intracellular transport, biodegradability, and decreased biodistribution. These properties result in the alleviation of the harmful consequences of conventional treatment protocols.
MATERIALS & METHODS: The administration of various bioactive molecules has been extensively investigated using nanostructured lipid carriers. In this article, theranostic applications of novel formulations of lipid nanocarriers combined or complexed with quantum dots, certain polymers, such as chitosan, and metallic nanoparticles (particularly gold) are reviewed. These formulations have demonstrated better controlled release features, improved drug loading capability, as well as a lower burst release rate. As a recent innovation in drug delivery, tocosomes and their unique advantages are also explained in the final section of this review.
Theranostic medicine requires nanocarriers with improved target-specific accumulation and bio-distribution. To this end, lipid-based nanocarrier systems and tocosomes combined with unique properties of quantum dots, biocompatible polymers, and metallic nanoparticles seem to be ideal candidates to be considered for safe and efficient drug delivery.
脂质纳米载体在封装和递送许多生物活性化合物方面具有巨大的潜力。它们在传统疾病管理和常规治疗方面表现出显著的优势。脂质纳米载体特定性质带来的益处包括药物的靶向沉积、改善药代动力学和药效学、增强内化和细胞内转运、生物降解性和减少生物分布。这些特性减轻了传统治疗方案的有害后果。
已经广泛研究了使用纳米结构脂质载体对各种生物活性分子的给药。在本文中，综述了脂质纳米载体的新型制剂与量子点、壳聚糖等某些聚合物以及金属纳米粒子（特别是金）结合或复合的治疗诊断应用。这些制剂表现出更好的控制释放特性、提高了药物负载能力，以及更低的初始突释率。作为药物递送的最新创新，微脂体及其独特的优势也在本综述的最后一部分进行了解释。
治疗诊断医学需要具有改进的靶向积累和生物分布的纳米载体。为此，基于脂质的纳米载体系统与具有独特性质的量子点、生物相容性聚合物和金属纳米粒子结合的微脂体似乎是被认为用于安全有效的药物递送的理想候选物。
