Yamashoji S, Kajimoto G
Biochim Biophys Acta. 1986 Nov 5;852(1):25-9. doi: 10.1016/0005-2728(86)90052-6.
Ferricyanide reduction catalyzed by vitamin K-3 was accompanied by the decrease in intracellular (NAD(P)H concentration of yeast cells, and the rate of ferricyanide reduction depended on intracellular concentration of NADH rather than NADPH. The addition of glucose to the cell suspensions enhanced both ferricyanide reduction and intracellular NADH concentration. The catalytic action of vitamin K-3 on ferricyanide reduction was observed in the presence of NADH and plasma membrane preparations. As the toxic action of vitamin K-3 on cell growth of yeast was enhanced by addition of ferricyanide, ferricyanide reduction catalyzed by vitamin K-3 may inhibit cell growth by decreasing intracellular NADH concentration.
维生素K-3催化的铁氰化物还原伴随着酵母细胞内（NAD(P)H浓度的降低，铁氰化物还原速率取决于细胞内NADH的浓度而非NADPH的浓度。向细胞悬液中添加葡萄糖可增强铁氰化物还原和细胞内NADH浓度。在存在NADH和质膜制剂的情况下观察到了维生素K-3对铁氰化物还原的催化作用。由于添加铁氰化物会增强维生素K-3对酵母细胞生长的毒性作用，维生素K-3催化的铁氰化物还原可能通过降低细胞内NADH浓度来抑制细胞生长。
