Department of Exercise Physiology, Sport Medicine Research Center, Sport Science Research Institute, Tehran University of Medical Science, Tehran, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Clin Nutr ESPEN. 2022 Apr;48:308-312. doi: 10.1016/j.clnesp.2022.01.029. Epub 2022 Jan 31.
The present study aimed to investigate the association between dietary acid load and the risk of type 2 diabetes (T2D) in Iranian adults.
This was a case-control study including 125 newly diagnosed T2D patients as cases and 190 healthy individuals as controls. A 168-item semi-quantitative food frequency questionnaire was applied to collect the participant's dietary intake information. Potential renal acid load (PRAL), net endogenous acid production (NEAP), protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio were derived from the nutrient intake.
We found that higher PRAL and NEAP scores are positively associated with the chance of T2D in the unadjusted model. Such that, when multiple potential confounders were taken into account, participants in the highest tertile of PRAL (OR: 4.37; 95% CI: 1.35-14.18) and NEAP score (OR: 2.24; 95% CI: 1.01-7.03) had a greater risk of T2D. No significant association was found between other indices including total protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio, and T2D risk.
The present findings suggest that high dietary acid load could be associated with the risk of T2D disease.
本研究旨在探讨伊朗成年人饮食酸负荷与 2 型糖尿病（T2D）风险之间的关系。
这是一项病例对照研究，包括 125 例新诊断的 T2D 患者作为病例和 190 例健康个体作为对照。应用 168 项半定量食物频率问卷收集参与者的饮食摄入信息。从营养素摄入中得出潜在肾酸负荷（PRAL）、净内源性酸产生（NEAP）、蛋白质/钾比、动物蛋白/钾比和植物蛋白/钾比。
我们发现，较高的 PRAL 和 NEAP 评分与未调整模型中 T2D 的发生几率呈正相关。当考虑多个潜在混杂因素时，PRAL（OR：4.37；95%CI：1.35-14.18）和 NEAP 评分（OR：2.24；95%CI：1.01-7.03）最高三分位的参与者患 T2D 的风险更高。总蛋白/钾比、动物蛋白/钾比和植物蛋白/钾比等其他指数与 T2D 风险之间没有显著关联。
本研究结果表明，高饮食酸负荷可能与 T2D 疾病的风险相关。
