Division of Cardiology, Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Division of Cardiology, Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Resuscitation. 2022 May;174:42-46. doi: 10.1016/j.resuscitation.2022.03.017. Epub 2022 Mar 21.
Metformin is a first-line diabetic therapy that improves survival in a wide number of ischemic pathologies. We tested the association of metformin with markers of cardiac and renal injury in diabetic post-arrest patients.
We performed a retrospective analysis of clinical outcomes in diabetic cardiac arrest patients with and without metformin therapy at a single academic medical center. We used generalized linear models to test the independent association of metformin, insulin, and other hypoglycemic agents with peak 24-hour serum creatinine and peak 24-hour serum troponin.
Metformin prescription at the time of SCA was independently associated with lower 24-hour peak serum troponin and lower 24-hour peak serum creatinine when compared to non-metformin patients.
Metformin pretreatment may offer cardiac and renal protection for diabetic patients during sudden cardiac arrest.
二甲双胍是一种一线糖尿病治疗药物，可改善多种缺血性疾病的患者的生存。我们检测了二甲双胍与糖尿病心搏骤停患者心脏和肾脏损伤标志物之间的关联。
我们对单家学术医疗中心中接受和未接受二甲双胍治疗的糖尿病心搏骤停患者的临床结局进行了回顾性分析。我们使用广义线性模型来检验二甲双胍、胰岛素和其他降血糖药物与 24 小时血清肌钙蛋白峰值和 24 小时血清肌酐峰值的独立相关性。
与非二甲双胍患者相比，SCA 时开具二甲双胍处方与 24 小时血清肌钙蛋白峰值和 24 小时血清肌酐峰值较低独立相关。
糖尿病患者在发生心搏骤停前使用二甲双胍可能会对心脏和肾脏起到保护作用。
