Anatomy Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Anatomy and Embryology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ultrastruct Pathol. 2022 Mar 4;46(2):204-216. doi: 10.1080/01913123.2022.2052779.
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most used drugs. The pathogenesis of aspirin-induced gastric ulceration includes blocking the activities of the cyclooxygenase enzymes (COX-1 and COX-2) leading to reduced mucus and bicarbonate secretion. contains many functional bioactive ingredients with antioxidant and anti-inflammatory activities, including phenolic phytochemicals and phycobiliprotein C-phycocyanin. To investigate the possible gastroprotective role of spirulina against aspirin-induced gastric mucosal insults. Forty adult male albino rats were randomly divided into four experimental groups. Group I (Control) and group II (Spirulina control) were given spirulina for 3 days, group III (Ulcer model) were given single dose of acetyl salicylic acid to induce ulcer and group IV (Treatment) were given spirulina for 3 days after induction of ulcer formation. Animals were sacrificed, stomachs were collected and processed for examination of light and scanning electron microscope histopathological examination. Statistical difference mucosal mucin area percentage among groups was determined and data were analyzed. Histological examination of the H&E-stained and combined Alcian-blue-PAS-stained sections of Group III rats illustrated severe destruction of the mucosal architecture and reduction of the mucin surface area while those examined for group IV illustrated minor affection of the gastric mucosa and mucin protective layer. Oxidant antioxidant markers: Nitric oxide (NO) is elevated, Glutathione (GSH) and superoxide dismutase (SOD) are reduced in aspirin treated group. The use of Spirulina restores the normal balance between the oxidant antioxidant system. Spirulina has a great potential in protecting the gastric mucosa against harmful effect of NSAID.
非甾体抗炎药（NSAIDs）是使用最广泛的药物之一。阿司匹林引起的胃溃疡的发病机制包括阻断环氧化酶酶（COX-1 和 COX-2）的活性，导致黏液和碳酸氢盐分泌减少。螺旋藻含有许多具有抗氧化和抗炎活性的功能性生物活性成分，包括酚类植物化学物质和藻蓝蛋白 C-藻蓝蛋白。研究螺旋藻对阿司匹林引起的胃黏膜损伤的可能胃保护作用。将 40 只成年雄性白化大鼠随机分为四组。第 I 组（对照组）和第 II 组（螺旋藻对照组）给予螺旋藻 3 天，第 III 组（溃疡模型组）给予单次乙酰水杨酸给药诱导溃疡，第 IV 组（治疗组）在诱导溃疡形成后给予螺旋藻 3 天。处死动物，收集胃并进行光镜和扫描电镜组织病理学检查。确定各组间黏膜粘蛋白面积百分比的统计学差异，并分析数据。H&E 染色和联合 Alcian-blue-PAS 染色的第 III 组大鼠切片的组织学检查显示黏膜结构严重破坏，粘蛋白表面面积减少，而第 IV 组检查显示胃黏膜和粘蛋白保护层受影响较小。氧化应激标志物：一氧化氮（NO）升高，谷胱甘肽（GSH）和超氧化物歧化酶（SOD）降低在阿司匹林治疗组中。螺旋藻的使用恢复了氧化应激系统的正常平衡。螺旋藻在保护胃黏膜免受 NSAID 有害影响方面具有巨大潜力。
