Department of General and Specialized Medicine, Sleep Disorders Center, University Hospital of Parma, Via Gramsci 14, 43126, Parma, Italy.
Department of General and Specialized Medicine, Neurology Unit, University Hospital of Parma, Parma, Italy.
Neurol Sci. 2022 Aug;43(8):4791-4796. doi: 10.1007/s10072-022-06008-9. Epub 2022 Mar 25.
Sleep disordersand excessive daytime sleepiness are among the commonest nonmotor symptoms in Parkinson disease (PD) and can contribute to significantly lower quality of life in affected patients. Various antiparkinson drugs exert a relevant influence on sleep quality, daily vigilance and well-being. In the latest years, administration of monoamine oxidase type B inhibitor (iMAO-B) medications in PD, especially rasagiline, has gained importance due to the hypothesized neuroprotective effect of these agents. Whereas the 'wakepromoting' effect of selegine, due to its activating amphetamine-like compounds, has been already described, less is known regarding the effect of rasagiline, a world-wide used iMAO-B drug. A pilot study was carried out to analyze the effects of rasagiline on sleep and healthrelated quality of life in a small cohort of PD patients. According to our results, PD patients treated with rasagiline referred better sleep quality, required less frequently hypnotic medication, complained of lower daytime sleepiness and presented higher scores in social functioning, perceived energy levels and emotional well-being. Albeit limited by the small sample size, our study suggests an intriguing role of rasagiline in improving sleep and quality of life in PD patients. Further studies are necessary to confirm our preliminary observations.
睡眠障碍和日间过度嗜睡是帕金森病（PD）中最常见的非运动症状之一，可显著降低受影响患者的生活质量。各种抗帕金森病药物对睡眠质量、日常警觉性和幸福感有相关影响。近年来，由于这些药物具有假设的神经保护作用，单胺氧化酶 B 抑制剂（iMAO-B）药物的给药，特别是雷沙吉兰，在 PD 中的重要性有所增加。虽然已经描述了司来吉兰由于其激活安非他命样化合物而具有“唤醒促进”作用，但对于雷沙吉兰（一种在全球范围内使用的 iMAO-B 药物）的作用知之甚少。进行了一项试点研究，以分析雷沙吉兰对一小群 PD 患者的睡眠和与健康相关的生活质量的影响。根据我们的结果，接受雷沙吉兰治疗的 PD 患者报告的睡眠质量更好，需要更频繁地使用催眠药物的频率较低，白天嗜睡程度较低，并且在社交功能、感知能量水平和情绪健康方面的得分更高。尽管受到样本量小的限制，但我们的研究表明雷沙吉兰在改善 PD 患者的睡眠和生活质量方面具有有趣的作用。需要进一步的研究来证实我们的初步观察。
