Hatcher Sarah M, Endres-Dighe Stacy M, Angulo Frederick J, Srivastava Amit, Nguyen Jennifer L, Khan Farid, Martin Catherine, Swerdlow David L, McLaughlin John M, Ubaka-Blackmore Nneka, Brown Linda Morris
RTI International, Research Triangle Park, NC 27709, USA.
Pfizer, Inc., New York, NY 10017, USA.
Vaccines (Basel). 2022 Mar 3;10(3):393. doi: 10.3390/vaccines10030393.
Observational studies are needed to demonstrate real-world vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outcomes. Our objective was to conduct a review of published SARS-CoV-2 VE articles, supplemented by preprints, during the first 6 months of COVID-19 vaccine availability. This review compares the effectiveness of completing the primary COVID-19 vaccination series against multiple SARS-CoV-2 disease presentations and disease severity outcomes in three population groups (general population, frontline workers, and older adults). Four hundred and seventy-one published articles and 47 preprints were identified. After title and abstract screening and full article review, 50 studies (28 published articles, 22 preprints) were included. VE results were reported for five COVID-19 vaccines and four combinations of COVID-19 vaccines. VE results for BNT162b2 were reported in 70.6% of all studies. Seventeen studies reported variant specific VE estimates; Alpha was the most common. This comprehensive review demonstrates that COVID-19 vaccination is an important tool for preventing COVID-19 morbidity and mortality among fully vaccinated persons aged 16 years and older and serves as an important baseline from which to follow future trends in COVID-19 evolution and effectiveness of new and updated vaccines.
需要进行观察性研究以证明针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关结局的实际疫苗效力（VE）。我们的目标是对已发表的SARS-CoV-2 VE文章进行综述，并辅以预印本，时间范围为COVID-19疫苗可用的前6个月。本综述比较了完成主要COVID-19疫苗接种系列针对三种人群（普通人群、一线工作者和老年人）中多种SARS-CoV-2疾病表现和疾病严重程度结局的有效性。共识别出471篇已发表文章和47篇预印本。经过标题和摘要筛选以及全文审查，纳入了50项研究（28篇已发表文章，22篇预印本）。报告了5种COVID-19疫苗和4种COVID-19疫苗组合的VE结果。在所有研究中，70.6%的研究报告了BNT162b2的VE结果。17项研究报告了特定变体的VE估计值；阿尔法变体是最常见的。这项全面综述表明，COVID-19疫苗接种是预防16岁及以上完全接种人群中COVID-19发病和死亡的重要工具，并作为跟踪COVID-19演变以及新疫苗和更新疫苗效力未来趋势的重要基线。
