儿童和青少年中 SARS-CoV-2 疫苗的有效性和安全性：一项系统评价和荟萃分析。
Effectiveness and Safety of SARS-CoV-2 Vaccines among Children and Adolescents: A Systematic Review and Meta-Analysis.
作者信息
Gao Peng, Cai Shan, Liu Qiao, Du Min, Liu Jue, Liu Min
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
出版信息
Vaccines (Basel). 2022 Mar 10;10(3):421. doi: 10.3390/vaccines10030421.
Background: The proportion of children and adolescents with COVID-19 had gradually increased according to data reported by WHO. However, there was no meta-analysis of effectiveness and safety of SARS-CoV-2 vaccines in children and adolescents. We aimed to provide investigation-based medical evidence and reference recommendations for children and adolescents in regard to SARS-CoV-2 vaccines. Methods: We systematically searched PubMed, Embase, and Web of Science from inception to 5 January 2022. RCTs and observational studies that examined the effectiveness and safety were included. Results: A total of 13 eligible studies were included for analysis. For the first dose, the effectiveness of SARS-CoV-2 vaccines against SARS-CoV-2 infection and COVID-19 was 88.5% (95% CI:15.7−98.4%, p = 0.033) and 84.3% (95% CI: 66.6−92.6%, p < 0.001) separately. For the second dose, the effectiveness against SARS-CoV-2 infection and COVID-19 was 91.6% (95% CI: 37.8−99.5%, p = 0.083) and 92.7 (95% CI: 82.2−97.0, p < 0.001) separately. Injection-site pain, fatigue, headache, anorexia, and axillary swelling were the top five adverse events after the first dose of SARS-CoV-2 vaccines. Fatigue, injection-site pain, headache, chills, and myalgia/muscle pain were the top five adverse events after the second dose of SARS-CoV-2 vaccines. Conclusions: SARS-CoV-2 vaccines had good effectiveness and safety in children and adolescents. We suggest that children and adolescents should get vaccinated as soon as possible to protect themselves and slow the spread of the pandemic.
背景
根据世界卫生组织报告的数据，感染新冠病毒的儿童和青少年比例逐渐上升。然而，尚无关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗在儿童和青少年中有效性和安全性的荟萃分析。我们旨在为儿童和青少年接种SARS-CoV-2疫苗提供基于调查的医学证据和参考建议。方法：我们系统检索了从数据库建立至2022年1月5日的PubMed、Embase和科学网。纳入了检验有效性和安全性的随机对照试验（RCT）和观察性研究。结果：共纳入13项合格研究进行分析。对于第一剂疫苗，SARS-CoV-2疫苗预防SARS-CoV-2感染和新冠病毒病的有效性分别为88.5%（95%置信区间：15.7−98.4%，p = 0.033）和84.3%（95%置信区间：66.6−92.6%，p < 0.001）。对于第二剂疫苗，预防SARS-CoV-2感染和新冠病毒病的有效性分别为91.6%（95%置信区间：37.8−99.5%，p = 0.083）和92.7%（95%置信区间：82.2−97.0，p < 0.001）。接种第一剂SARS-CoV-2疫苗后，注射部位疼痛、疲劳、头痛、厌食和腋窝肿胀是前五项不良事件。接种第二剂SARS-CoV-2疫苗后，疲劳、注射部位疼痛、头痛、寒战和肌痛/肌肉疼痛是前五项不良事件。结论：SARS-CoV-2疫苗在儿童和青少年中具有良好的有效性和安全性。我们建议儿童和青少年应尽快接种疫苗以保护自己并减缓疫情传播。
Zotero 插件