Bertram Ralph, Bartsch Vanessa, Sodmann Johanna, Hennig Luca, Müjde Engin, Stock Jonathan, Ruedig Vivienne, Sodmann Philipp, Todt Daniel, Steinmann Eike, Hitzl Wolfgang, Steinmann Joerg
Institute of Clinical Hygiene, Medical Microbiology and Infectiology, Klinikum Nürnberg, Paracelsus Medical University, 90419 Nuremberg, Germany.
Study Program in Human Medicine, Paracelsus Medical University, 90419 Nuremberg, Germany.
Vaccines (Basel). 2022 Mar 11;10(3):432. doi: 10.3390/vaccines10030432.
In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants' vaccination status.
2022年初，2019冠状病毒病（COVID-19）仍是一项全球挑战。COVID-19由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）越来越多的变种引起。在此，我们报告了一起与一场学生节日活动相关的SARS-CoV-2突破性感染疫情，该活动于2021年10月在德国巴伐利亚州北部举行，有100名大多已接种疫苗的宾客参加。数据通过对宾客的回顾性访谈获得。共有95名学生参与了研究，其中94人已完全接种疫苗，24人报告感染了德尔塔变种。对15个检测变量的相关性分析显示，在活动中停留的时间、与假定的索引病例的交谈以及同源病毒载体疫苗接种方案是感染的重要风险因素。与较高感染率相关的无统计学意义的观察结果包括上次接种疫苗后的时间、共用饮水容器以及活动中个人之间的接触次数。我们的数据表明，如果不采取预防措施，德尔塔变种的突破性感染率会很高。为了限制感染风险，无论参与者的疫苗接种状况如何，都应考虑对参与者进行高质量检测作为聚会的一项强制性措施。
