Sikora Dominika, Rzymski Piotr
Department of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznań, Poland.
Doctoral School, Poznan University of Medical Sciences, Fredry St. 10, 61-701 Poznań, Poland.
Vaccines (Basel). 2022 Mar 12;10(3):437. doi: 10.3390/vaccines10030437.
The COVID-19 vaccination campaigns were met with a varying level of vaccine hesitancy in Europe. We analyzed the potential relationships between COVID-19 vaccine coverage in different countries of the European Economic Area and rates of infection, hospitalizations, admissions to intensive care units (ICU), and deaths during the autumn 2021 SARS-CoV-2 wave (September-December). Significant negative correlations between infection rates and the percentage of fully vaccinated individuals were found during September, October, and November, but not December. The loss of this protective effect in December is likely due to the emergence of the omicron (B.1.1.529) variant, better adapted to evade vaccine-induced humoral immunity. For every considered month, the negative linear associations between the vaccine coverage and mean number of hospitalizations (r= -0.61 to -0.88), the mean number of ICU admissions (r= -0.62 to -0.81), and death rate (r= -0.64 to -0.84) were observed. The results highlight that vaccines provided significant benefits during autumn 2021. The vaccination of unvaccinated individuals should remain the primary strategy to decrease the hospital overloads, severe consequences of COVID-19, and deaths.
在欧洲，新冠疫苗接种运动遭遇了不同程度的疫苗犹豫情况。我们分析了欧洲经济区不同国家的新冠疫苗接种率与2021年秋季（9月至12月）严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫情期间的感染率、住院率、重症监护病房（ICU）收治率和死亡率之间的潜在关系。在9月、10月和11月发现感染率与完全接种疫苗个体的百分比之间存在显著负相关，但12月没有。12月这种保护作用的丧失可能是由于奥密克戎（B.1.1.529）变体的出现，该变体更善于逃避疫苗诱导的体液免疫。对于每个考虑的月份，均观察到疫苗接种率与平均住院人数（r = -0.61至-0.88）、平均ICU收治人数（r = -0.62至-0.81）和死亡率（r = -0.64至-0.84）之间存在负线性关联。结果表明，疫苗在2021年秋季带来了显著益处。对未接种疫苗的个体进行接种仍应是减轻医院负担、降低新冠严重后果和死亡率的主要策略。
