Virachith Siriphone, Lao Mapor, Inthepphavong Magnoula, Inthalath Saythong, Hübschen Judith M, Kounnavong Sengchanh, Sayasone Somphou, Black Antony P
LaoLuxLab, Institut Pasteur du Laos, Vientiane Capital 01030, Laos.
Lao Tropical and Public Health Institute, Ministry of Health, Vientiane Capital 01030, Laos.
Vaccines (Basel). 2022 Mar 17;10(3):463. doi: 10.3390/vaccines10030463.
Xaysomboun province has some of the lowest health indicators in Lao People's Democratic Republic (PDR). This cross-sectional study aimed to determine the vaccination, susceptibility and exposure status of the population to hepatitis B virus (HBV), measles, rubella, and tetanus. Participants aged 5 years and older were randomly selected from four districts. From each enrolled participant, demographic data and 5 mL of blood sample were taken. HBV surface antigen (HBsAg) and antibodies against HBV, measles, rubella, and tetanus were detected by ELISA. A total of 363 participants (age 5 to 80 years) were included. HBV exposure, as determined by anti-HBV core (anti-HBc) antibodies, was 56.2% overall, and was significantly higher among those aged ≥21 years (78.1%). HBsAg was detected in 9.4% overall and increased to 20% in ages 31-40 years. Only 13.8% of participants had serology indicative of vaccination (anti-HBs positive, anti-HBc negative). Seroprotection against measles was 74.6% overall but only 41.7% in children aged 5-10 years. Anti-rubella IgG was 94.2% overall and high in all age groups. Tetanus seroprevalence was only 47.4% overall but significantly higher in females aged 31-40 (75.6%). We suggest strengthening of routine and booster HBV, measles, and tetanus vaccine coverage in Xaysomboun province.
赛宋奔省的一些健康指标在老挝人民民主共和国处于最低水平。这项横断面研究旨在确定该人群对乙型肝炎病毒（HBV）、麻疹、风疹和破伤风的疫苗接种情况、易感性和暴露状况。从四个区随机选取5岁及以上的参与者。从每位入选参与者处获取人口统计学数据和5毫升血样。通过酶联免疫吸附测定法检测HBV表面抗原（HBsAg）以及针对HBV、麻疹、风疹和破伤风的抗体。总共纳入了363名参与者（年龄在5至80岁之间）。通过抗HBV核心（抗-HBc）抗体确定的HBV暴露总体为56.2%，在21岁及以上人群中显著更高（78.1%）。总体HBsAg检测率为9.4%，在31至40岁年龄段升至20%。只有13.8%的参与者血清学指标显示接种过疫苗（抗-HBs阳性，抗-HBc阴性）。总体麻疹血清保护率为74.6%，但在5至10岁儿童中仅为41.7%。抗风疹IgG总体为94.2%，在所有年龄组中都很高。破伤风血清阳性率总体仅为47.4%，但在31至40岁女性中显著更高（75.6%）。我们建议在赛宋奔省加强常规和加强剂量的HBV、麻疹和破伤风疫苗接种覆盖率。
