Grygorczuk Sambor, Dunaj-Małyszko Justyna, Sulik Artur, Toczyłowski Kacper, Czupryna Piotr, Żebrowska Agnieszka, Parczewski Miłosz
Department of the Infectious Diseases and Neuroinfections, Faculty of Medicine, Medical University of Białystok, ul. Żurawia 14, 15-540 Białystok, Poland.
Department of the Pediatric Infectious Diseases, Faculty of Medicine, Medical University of Białystok, ul. Jerzego Waszyngtona 17, 15-274 Białystok, Poland.
Pathogens. 2022 Mar 4;11(3):318. doi: 10.3390/pathogens11030318.
The host factors influencing the susceptibility to and the severity of tick-borne encephalitis (TBE) are poorly defined. The loss-of-function mutation in the chemokine receptor gene was identified as a risk factor for West Nile encephalitis and possibly for TBE, suggesting a protective role of CCR5 in encephalitis.
We studied the genotype in 205 TBE patients stratified by a clinical presentation and 257 controls from the same endemic area (Podlasie, Poland). The genotype distribution between the groups and differences between TBE patients with different genotypes were analyzed.
There were 36 (17.6%) heterozygotes and 3 (1.5%) homozygotes in the TBE group, with no statistically significant difference in comparison with the controls. The allele did not associate with the clinical presentation or the severity of TBE. The cerebrospinal fluid (CSF) inflammatory parameters did not differ between the wild-type () and genotype patients. The TBE clinical presentation and CSF parameters in three homozygotes were unremarkable.
The lack of association of with the risk and clinical presentation of TBE challenges the suspected CCR5 protective role. CCR5 is not indispensable for the effective immune response against the TBE virus.
影响蜱传脑炎（TBE）易感性和严重程度的宿主因素尚不清楚。趋化因子受体基因的功能丧失突变被确定为西尼罗河脑炎的危险因素，也可能是TBE的危险因素，提示CCR5在脑炎中具有保护作用。
我们研究了205例按临床表现分层的TBE患者和来自同一流行地区（波兰波德拉谢）的257例对照者的CCR5基因型。分析了两组之间的基因型分布以及不同基因型TBE患者之间的差异。
TBE组中有36例（17.6%）杂合子和3例（1.5%）纯合子，与对照组相比无统计学显著差异。CCR5等位基因与TBE的临床表现或严重程度无关。野生型（CCR5+/+）和CCR5基因型患者的脑脊液（CSF）炎症参数无差异。3例CCR5纯合子患者的TBE临床表现和CSF参数无异常。
CCR5与TBE风险和临床表现缺乏关联，这对CCR5的推测性保护作用提出了挑战。CCR5对于针对TBE病毒的有效免疫反应并非不可或缺。
