化学修饰的细胞外囊泡及其在放射性标记和药物递送中的应用。
Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery.
作者信息
N'Diaye Elisa-Racky, Orefice Nicola Salvatore, Ghezzi Catherine, Boumendjel Ahcène
机构信息
Faculty of Pharmacy, Université Grenoble Alpes, 38700 La Tronche, France.
Laboratoire Radiopharmaceutiques Biocliniques (LRB), INSERM U1039, Faculté de Médecine La Tronche, Université Grenoble Alpes, 38000 Grenoble, France.
出版信息
Pharmaceutics. 2022 Mar 16;14(3):653. doi: 10.3390/pharmaceutics14030653.
Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs' rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs' use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers.
细胞外囊泡（EVs）已被开发为生物启发的药物递送系统（DDS），应用于生物医学领域。与合成纳米颗粒相比，EVs具有更多优势：它们天生就具备跨越细胞外和细胞内屏障的能力。此外，它们能够将功能性生物分子从一个细胞传递到体内远处的另一个细胞。这些优势，再加上在体内实验中取得的令人鼓舞的结果，清楚地证明了EVs在药物递送方面的潜力。然而，由于难以找到一种与EVs合理的临床治疗用途相一致的化学方法，药物递送领域的研究人员对EVs的应用寄予了更多期望。因此，本综述收集了当前处理EVs与药物和放射性示踪剂偶联的化学方法的相关知识。
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