Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman 7616913439, Iran.
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
Sensors (Basel). 2022 Mar 14;22(6):2238. doi: 10.3390/s22062238.
Many studies have addressed electrochemical biosensors because of their simple synthesis process, adjustability, simplification, manipulation of materials' compositions and features, and wide ranges of detection of different kinds of biomedical analytes. Performant electrochemical biosensors can be achieved by selecting materials that enable faster electron transfer, larger surface areas, very good electrocatalytic activities, and numerous sites for bioconjugation. Several studies have been conducted on the metal-organic frameworks (MOFs) as electrode modifiers for electrochemical biosensing applications because of their respective acceptable properties and effectiveness. Nonetheless, researchers face challenges in designing and preparing MOFs that exhibit higher stability, sensitivity, and selectivity to detect biomedical analytes. The present review explains the synthesis and description of MOFs, and their relative uses as biosensors in the healthcare sector by dealing with the biosensors for drugs, biomolecules, as well as biomarkers with smaller molecular weight, proteins, and infectious disease.
许多研究都涉及电化学生物传感器，因为它们具有简单的合成工艺、可调节性、简化性、对材料组成和特性的操控，以及对各种生物医学分析物的广泛检测范围。通过选择能够实现更快电子转移、更大表面积、非常好的电催化活性和更多用于生物结合的位点的材料，可以实现高性能的电化学生物传感器。由于各自具有可接受的性质和有效性，已经有几项关于金属-有机骨架 (MOFs) 作为电化学生物传感应用的电极修饰剂的研究。尽管如此，研究人员在设计和制备表现出更高稳定性、灵敏度和选择性以检测生物医学分析物的 MOFs 方面仍面临挑战。本综述通过处理用于药物、生物分子以及具有较小分子量的生物标志物、蛋白质和传染病的生物传感器，解释了 MOFs 的合成和描述，以及它们在医疗保健领域作为生物传感器的相对用途。
