Catala J, Bonnafous R, Dutrillaux M C, Hollande E
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;52(6):539-51. doi: 10.1007/BF02889992.
In the rabbit, pancreatic duct ligation leads to serious disturbances of the pancreatic endocrine parenchyma. Immunocytochemical studies conducted over a short period (between 5 and 30 days post ligation) allow observation of a progressive dissociation of the Langerhans islets which initially affects the splenic part of the pancreas, a region where numerous large islets are found. This dissociation is followed by a dispersion of small heterologous endocrine cell clusters or isolated endocrine cells in a connective tissue which replace the exocrine parenchyma. On the 30th day after ligation ultrastructural studies show marked degranulation of the B cells demonstrating the great fragility of these cells. These observations of insular dissociation, scattering of the different endocrine cells and impairment of B cells are often reported in experimental and pathological studies of the pancreas.
在兔身上，胰管结扎会导致胰腺内分泌实质出现严重紊乱。在短时间内（结扎后5至30天）进行的免疫细胞化学研究能够观察到朗格汉斯胰岛的渐进性解离，这种解离最初影响胰腺的脾部，该区域有许多大的胰岛。这种解离之后是小的异源性内分泌细胞簇或孤立的内分泌细胞在取代外分泌实质的结缔组织中分散。结扎后第30天，超微结构研究显示B细胞有明显的脱颗粒现象，表明这些细胞非常脆弱。胰腺的实验和病理研究中经常报道这些胰岛解离、不同内分泌细胞散射以及B细胞受损的观察结果。
