基于 F13L、D4R 和 K1L 基因的重组 MVA 选择方法比较。
Comparison of Recombinant MVA Selection Methods Based on F13L, D4R and K1L Genes.
机构信息
Federal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical Biological Agency, 119121 Moscow, Russia.
Izmerov Research Institute of Occupational Health, 105275 Moscow, Russia.
出版信息
Viruses. 2022 Mar 4;14(3):528. doi: 10.3390/v14030528.
Modified vaccinia Ankara (MVA) is a promising vaccine vector due to its highly attenuated phenotype and good immunogenicity. However, obtaining a new recombinant MVA remains a tedious and laborious procedure involving many rounds of plaque purification. Recombinant MVA generation can be greatly improved and facilitated by different selection techniques. Here, we describe a comparison between techniques based on K1L, F13L and D4R genes.
改良安卡拉痘苗病毒（MVA）是一种很有前途的疫苗载体，因为它具有高度减毒的表型和良好的免疫原性。然而，获得新的重组 MVA 仍然是一个繁琐而费力的过程，涉及许多轮的蚀斑纯化。不同的选择技术可以极大地改进和促进重组 MVA 的产生。在这里，我们描述了基于 K1L、F13L 和 D4R 基因的技术之间的比较。
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