Coon J S, Weinstein R S
Hum Pathol. 1986 Nov;17(11):1089-106. doi: 10.1016/s0046-8177(86)80413-0.
The expression of BGR-Ags is often aberrant in human carcinomas. The observation that BGR-Ag expression in human bladder carcinomas correlates with prognosis for patients with these tumors is especially interesting in light of the numerous reports of correlations between cell surface glycosylation and malignant phenotype in experimental animal tumors. Many observations suggest how this relation might be mediated. It seems reasonable to anticipate that the study of the BGR-Ags and their expression in carcinoma may emerge from its current predominantly descriptive phase and become an important part of the investigation of human tumor biology.
BGR抗原在人类癌症中的表达常常异常。鉴于在实验动物肿瘤中细胞表面糖基化与恶性表型之间存在众多相关性报道，人类膀胱癌中BGR抗原表达与这些肿瘤患者预后相关这一观察结果尤其引人关注。许多观察结果提示了这种关系可能的介导方式。可以合理预期，对BGR抗原及其在癌症中表达的研究可能会从目前主要的描述阶段发展出来，成为人类肿瘤生物学研究的重要组成部分。
