来自易感和抗性大鼠的脾细胞对伯氏疟原虫的抗体依赖性和非依赖性细胞毒性活性。
Antibody-dependent and -independent cytotoxic activity of spleen cells for Plasmodium berghei from susceptible and resistant rats.
作者信息
Orago A S, Solomon J B
出版信息
Immunology. 1986 Oct;59(2):283-8.
Abstract
Antibody-dependent cell cytotoxicity (ADCC) mediated by spleen cells from 30- or 50-day old rats against 51Cr-labelled rat erythrocytes parasitized by Plasmodium berghei in the presence of anti-P. berghei antibody showed only slight age differences. However, in the absence of specific antibody, the total cell-mediated cytotoxicy (CMC) per spleen was four times higher in the spleen cells from 50-day-old rats compared with those from 30-day-old rats. CMC accounted for about 50% of total cytotoxic activity in 50-day-old rat spleens. Spleen cells mediating ADCC and CMC are Thy-1.1 positive, and those mediating ADCC are nearly all non-adherent to Sephadex G-10 columns.
摘要
在抗伯氏疟原虫抗体存在的情况下，30日龄或50日龄大鼠的脾细胞介导的针对被伯氏疟原虫寄生的51Cr标记大鼠红细胞的抗体依赖性细胞毒性（ADCC）仅表现出轻微的年龄差异。然而，在没有特异性抗体的情况下，50日龄大鼠脾细胞的每脾总细胞介导细胞毒性（CMC）比30日龄大鼠的脾细胞高四倍。在50日龄大鼠脾脏中，CMC约占总细胞毒性活性的50%。介导ADCC和CMC的脾细胞是Thy-1.1阳性的，而介导ADCC的细胞几乎都不黏附于葡聚糖凝胶G-10柱。
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