疟疾中脾脏介导的红细胞细胞毒性
Splenic mediated erythrocyte cytotoxicity in malaria.
作者信息
Coleman R M, Rencricca N J, Stout J P, Brissette W H, Smith D M
出版信息
Immunology. 1975 Jul;29(1):49-54.
Abstract
Cell-mediated cytotoxicity in virulent rodent malaria has been demonstrated in vitro, whereby splenic cells effected specific lysis of 51Cr-labelled erythrocytes from parasitized animals. More than one cellular cytolytic effector system appeared to be operative in the mouse. One effector system involved splenic macrophages, from normal or immune animals, which were increasingly cytotoxic to target cells in the presence of antibody. A second effector system involved nylonpurified immune spleen cells which were significantly more cytotoxic than similary prepared normal spleen cells in the presence of immune serum. Although antibody alone was not cytolytic, the data strengthen the concept that immune spleen cells and antibody can interact in a co-operative fashion to mediate cytotoxic reactions in malaria.
摘要
在体外已证实，恶性啮齿动物疟疾中存在细胞介导的细胞毒性，即脾细胞对来自受感染动物的51Cr标记红细胞进行特异性裂解。在小鼠中似乎有不止一种细胞溶解效应系统起作用。一种效应系统涉及来自正常或免疫动物的脾巨噬细胞，在抗体存在的情况下，它们对靶细胞的细胞毒性越来越大。第二种效应系统涉及经尼龙纯化的免疫脾细胞，在免疫血清存在的情况下，这些细胞的细胞毒性明显高于类似制备的正常脾细胞。虽然单独的抗体没有细胞溶解作用，但这些数据强化了免疫脾细胞和抗体可以以协同方式相互作用以介导疟疾细胞毒性反应的概念。
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