Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Am J Transplant. 2022 Jul;22(7):1813-1822. doi: 10.1111/ajt.17044. Epub 2022 Apr 6.
The ability of kidney transplant candidates to travel outside of their usual place of care varies by sociodemographic factors, potentially exacerbating disparities in access. We used Transplant Referral Regions (TRRs) to overcome previous methodological barriers of using geographic distance to assess the characteristics and outcomes of patients listed for kidney transplant at centers in neighboring TRR or beyond neighboring TRRs. Among listed kidney transplant candidates, 20.9% traveled to a neighbor and 5.6% beyond a neighbor. A higher proportion of travelers were White, had some college education, and lived in ZIP codes with lower poverty. Travel to a neighbor was associated with a 7% increase in likelihood of deceased donor transplant (cHR: 1.07, 95% CI: 1.05, 1.09) and traveling beyond a neighbor with a 19% increase (cHR: 1.19, 95% CI: 1.15, 1.24). Travelers had similar rates of living donor transplant and waitlist mortality as patients who did not travel; those who traveled beyond a neighbor had slightly lower posttransplant mortality (HR: 0.91, 95% CI: 0.83, 0.99). In conclusion, the ability to travel outside of the recipient's assigned TRR increases access to transplantation and improves long-term survival.
肾移植候选人前往常规治疗地点以外的地方的能力因社会人口因素而异,这可能会加剧获得移植的机会不平等。我们使用移植转介区域(TRR)来克服以前使用地理距离评估在邻近 TRR 或邻近 TRR 以外的中心进行肾移植的患者的特征和结果的方法学障碍。在列出的肾移植候选人中,有 20.9%的患者前往邻近地区,5.6%的患者前往邻近地区以外的地区。更多的旅行者是白人,有一定的大学学历,并且居住在贫困程度较低的邮政编码地区。前往邻近地区的患者接受已故供体移植的可能性增加了 7%(校正 HR:1.07,95%CI:1.05,1.09),而前往邻近地区以外的患者接受移植的可能性增加了 19%(校正 HR:1.19,95%CI:1.15,1.24)。旅行者与未旅行者的活体供体移植和等待名单死亡率相似;而前往邻近地区以外的旅行者的移植后死亡率略低(HR:0.91,95%CI:0.83,0.99)。总之,能够前往受者指定的 TRR 以外的地方增加了移植的机会并提高了长期生存率。