Reynolds L P
J Anim Sci. 1986;62 Suppl 2:47-61. doi: 10.1093/ansci/62.2.47.
Recent studies of utero-ovarian blood flow have indicated an interaction between the gravid uterus and the ovary in maintaining luteal function during early pregnancy. On days critical for the continuation of pregnancy, blood flow to the corpus luteum (CL) increases several-fold, coincident with an increase in concentrations of progesterone (P4) in systemic blood. Enhanced ovarian secretion of P4 may amplify the vasodilatory "signal" of the conceptus and thus ensure an adequate uterine blood supply to support early fetal growth. Utero-ovarian vasodilation during early pregnancy may not only stimulate luteal function directly but also enhance transport of luteotropic substances to the ovary. Possible candidates for the vasodilatory factor(s) secreted from the early gravid uterus include estrogens and prostaglandins (PG) E. In addition, conversion of estrogens to their catechol forms, which have both vasodilatory and luteotropic activities, may be important for the successful establishment of pregnancy.
近期关于子宫 - 卵巢血流的研究表明，在妊娠早期，妊娠子宫与卵巢之间存在相互作用以维持黄体功能。在对妊娠持续至关重要的日子里，黄体（CL）的血流量增加数倍，同时全身血液中孕酮（P4）浓度升高。卵巢分泌P4的增加可能会放大孕体的血管舒张“信号”，从而确保有足够的子宫血液供应以支持早期胎儿生长。妊娠早期子宫 - 卵巢血管舒张不仅可能直接刺激黄体功能，还可能增强促黄体物质向卵巢的转运。早期妊娠子宫分泌的血管舒张因子的可能候选物包括雌激素和前列腺素（PG）E。此外，雌激素转化为具有血管舒张和促黄体活性的儿茶酚形式可能对成功建立妊娠很重要。
