Laboratório Experimental de Morfologia - Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel, Paraná, Brazil.
Laboratório de Plasticidade Morfofuncional - Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Anat Rec (Hoboken). 2022 Nov;305(11):3307-3316. doi: 10.1002/ar.24922. Epub 2022 Apr 11.
Glyphosate (GBH) is a worldwide consumption pesticide and is used in the formulation of Roundup®, one of the most commercialized herbicides in the world. Maternal exposure to this herbicide can promote changes and adaptations in the offspring; however, the effects on skeletal muscle are poorly understood. In this sense, the present study sought to evaluate the effect of exposure to GBH on the characteristics of the soleus (SOL) and extensor digitorum longus (EDL) muscles. C57BL/6 pregnant female mice were divided into two groups: control (CTL) receiving water and glyphosate (GBH; n = 6) receiving 0.5% glyphosate. Male puppies were designated according to the group to which the mothers belonged, such as CTL-F1 and GBH-F1 and then euthanized at 150 days of age. There was a reduction in body weight and nasoanal length of animals exposed to GBH, while there was an increase in EDL weight, reduction in the proportion of fibers and number of nuclei, and an increase in the connective tissue of the SOL. The animals exposed to GBH presented higher values of body characteristics, mainly adiposity gain, while they presented a reduction in neuromuscular junctions (NMJ), and an increase in fibrosis in the SOL muscle, while there was a reduction in the number of nuclei, and an increase in the weight of the EDL muscle. These findings indicate that glyphosate can promote changes in the offspring's body growth, the deposition of adipose panicles and its effects on muscle can lead to changes in the structure and functioning of this tissue.
草甘膦（GBH）是一种全球范围内使用的农药，用于配制世界上最商业化的除草剂之一——农达（Roundup®）。母体暴露于这种除草剂可能会促进后代发生变化和适应；然而，其对骨骼肌的影响知之甚少。从这个意义上说，本研究旨在评估暴露于草甘膦对比目鱼肌（SOL）和趾长伸肌（EDL）肌肉特征的影响。C57BL/6 孕鼠分为两组：对照组（CTL）接受水和草甘膦（GBH；n=6）接受 0.5%草甘膦。雄性幼犬根据母亲所属的组别进行命名，例如 CTL-F1 和 GBH-F1，然后在 150 日龄时安乐死。暴露于草甘膦的动物体重和鼻肛长降低，而 EDL 重量增加，纤维比例和核数减少，SOL 结缔组织增加。暴露于草甘膦的动物表现出更高的身体特征值，主要是脂肪堆积增加，而神经肌肉接头（NMJ）减少，SOL 肌肉纤维化增加，核数减少，EDL 肌肉重量增加。这些发现表明，草甘膦可能会促进后代的身体生长变化，脂肪颗粒的沉积及其对肌肉的影响可能导致该组织的结构和功能发生变化。
