Department of Dermatology and Venereal Diseases, Maribor University Medical Centre, Maribor, Slovenia.
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Acta Dermatovenerol Alp Pannonica Adriat. 2022 Mar;31(Suppl):S2-S6.
Palisaded neutrophilic granulomatous dermatitis (PNGD) is a rare histopathological pattern belonging to a group of cutaneous granulomatous eruptions that typically manifests with asymptomatic skin-colored, erythematous, or violaceous papules or nodules. PNGD can be triggered by various systemic conditions, including medications and autoimmune and autoinflammatory disorders, as well as malignancies; for example, lymphoproliferative disorders. Therefore, in patients with PNGD an extended diagnostic workup is mandatory as well as follow-up in the case of idiopathic PNGD. To the best of our knowledge, this is the first reported case in the literature of PNGD causally related to a relapse of HLA-B27-negative axial spondyloarthritis.
栅栏状中性粒细胞性肉芽肿性皮炎 (PNGD) 是一种罕见的组织病理学模式，属于一组皮肤肉芽肿性发疹，通常表现为无症状的皮肤色、红斑或紫色丘疹或结节。PNGD 可由各种系统性疾病引起，包括药物和自身免疫及自身炎症性疾病以及恶性肿瘤；例如，淋巴增生性疾病。因此，对于患有 PNGD 的患者，必须进行广泛的诊断性检查，并且对于特发性 PNGD 还需要进行随访。据我们所知，这是文献中首例报道的与 HLA-B27 阴性轴性脊柱关节炎复发相关的 PNGD 病例。
