Elhendawy Mahmoud A, Omran Ahmed M, Hasan Abdulkarim, Basiony Mostafa, Abdelmaksoud Ayman, Elbasateeny Samah S
Plastic Surgery, Faculty of Medicine, Al-Azhar University, Assiut, EGY.
Plastic Surgery, Faculty of Medicine, Al-Azhar University, Damietta, EGY.
Cureus. 2024 Jul 20;16(7):e64965. doi: 10.7759/cureus.64965. eCollection 2024 Jul.
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inflammatory cutaneous disorder of unknown etiology that typically occurs in association with systemic disease. Rheumatoid arthritis and systemic lupus erythematosus are the most common associated diseases. PNGD manifests as skin-colored to erythematous papules and plaques, mainly on the extremities. However, to the best of our knowledge, no cases of PNGD in the vulva have been reported in foreign literature to date. Herein, we report the first case of a 31-year-old female with systemic lupus erythematosus disease who presented multiple plaques and a pigmented, rough, mamillated skin surface affecting the vulva, leading to disfigurement of the vulva and interfering with sexual intercourse due to severe pain, irritation, and frequent infection. Surgical excision of the whole lesion with reconstruction of the vulva was done in two sessions and histologically diagnosed as PNGD.
栅栏状中性粒细胞和肉芽肿性皮炎（PNGD）是一种病因不明的炎症性皮肤病，通常与全身性疾病相关。类风湿性关节炎和系统性红斑狼疮是最常见的相关疾病。PNGD表现为肤色至红斑丘疹和斑块，主要位于四肢。然而，据我们所知，国外文献至今尚未报道过外阴部PNGD病例。在此，我们报告首例31岁患有系统性红斑狼疮的女性病例，其外阴出现多个斑块，皮肤表面色素沉着、粗糙呈乳头状，导致外阴毁损，并因严重疼痛、刺激和频繁感染而影响性交。分两期对外阴病变进行了全切除并重建，组织学诊断为PNGD。
