Department of Dermatovenerology, Novo mesto General Hospital, Novo Mesto, Slovenia.
Department of Immunopathology, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Acta Dermatovenerol Alp Pannonica Adriat. 2022 Mar;31(Suppl):S36-S38.
Granulomatous cheilitis or Miescher's cheilitis is a rare granulomatous disorder defined by recurrent lip swelling or edema of other facial soft tissues. Histopathology shows non-caseous granulomas and multinucleated giant cells. The exact etiology is unknown, although genetic background, immunological irregularities, and systemic or infectious diseases contribute to the onset of disease. There are no treatment guidelines. The usual treatment options include systemic or intralesional corticosteroids, a spectrum of antibiotics, and immunosuppressants. A 63-year-old patient presenting with lip swelling and simultaneous swelling of other facial soft tissues was diagnosed with granulomatous cheilitis. The symptoms occurred 3 weeks after SARS-CoV-2 infection. Initial treatment with systemic corticosteroids and antihistamines was inadequate. Here we report successful treatment with a combination of doxycycline and metronidazole.
肉芽肿性唇炎或米舍尔唇炎是一种罕见的肉芽肿性疾病，其特征为复发性唇部肿胀或其他面部软组织水肿。组织病理学表现为非干酪样肉芽肿和多核巨细胞。确切病因尚不清楚，尽管遗传背景、免疫异常和系统性或感染性疾病都有助于疾病的发生。目前尚无治疗指南。常用的治疗方法包括全身或局部皮质类固醇、广谱抗生素和免疫抑制剂。一名 63 岁的患者因唇部肿胀和其他面部软组织同时肿胀就诊，被诊断为肉芽肿性唇炎。症状在 SARS-CoV-2 感染后 3 周出现。最初使用全身皮质类固醇和抗组胺药治疗效果不佳。在此，我们报告了使用多西环素和甲硝唑联合治疗成功的病例。
