Lof J, Smits K, Melotte V, Kuil L E
Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Neurosci Biobehav Rev. 2022 May;136:104634. doi: 10.1016/j.neubiorev.2022.104634. Epub 2022 Mar 23.
Obesity is a complex disease with many co-morbidities, including impaired cognitive functions. Obese individuals often contain an aberrant microbiota. Via the microbiota-gut-brain axis, the altered microbiota composition can affect cognition or induce anxiety- or depressive-like behavior. Probiotics have been shown to alleviate both obesity- and neurobehavioral disorder-related symptoms. Here, we evaluated previously published results on the effectiveness of probiotic intervention in alleviating obesity- or high-fat diet (HFD)-related cognitive impairment, depression and anxiety. A systematic search was performed in PubMed, Embase, and Google Scholar until June 2021 to identify relevant articles. Seventeen studies were included: one human and sixteen animal studies. Overall, the findings support the beneficial health effect of probiotics on HFD-induced cognitive impairment and anxiety. However, the results suggest that multi-strain probiotic treatments should be used with caution, especially in the absence of HFD-induced impairment. Future studies should overcome the large variation in study design and high risk of bias found in the current evidence. Nevertheless, probiotic treatment, in particular using the Lactobacillus genus, seems promising.
肥胖是一种复杂的疾病，伴有多种合并症，包括认知功能受损。肥胖个体通常含有异常的微生物群。通过微生物群-肠道-脑轴，改变的微生物群组成可影响认知或诱发焦虑样或抑郁样行为。益生菌已被证明可减轻与肥胖和神经行为障碍相关的症状。在此，我们评估了先前发表的关于益生菌干预减轻肥胖或高脂饮食（HFD）相关认知障碍、抑郁和焦虑有效性的结果。在PubMed、Embase和谷歌学术上进行了系统检索，直至2021年6月，以识别相关文章。纳入了17项研究：1项人体研究和16项动物研究。总体而言，研究结果支持益生菌对HFD诱导的认知障碍和焦虑具有有益的健康影响。然而，结果表明，应谨慎使用多菌株益生菌治疗，尤其是在没有HFD诱导损伤的情况下。未来的研究应克服当前证据中发现的研究设计差异大以及偏倚风险高的问题。尽管如此，益生菌治疗，特别是使用乳酸杆菌属，似乎很有前景。
