Neumann H G
J Cancer Res Clin Oncol. 1986;112(2):100-6. doi: 10.1007/BF00404390.
Many findings support the notion that the generation of DNA adducts by aromatic amines is causally related to carcinogenesis. Adducts have been identified in most cases and representative examples are reviewed. However, extent and persistence of DNA adducts (DNA dose) does not correlate satisfactorily with the tumor response of different tissues. Distribution of DNA damage, repair, indirect and secondary DNA damage are discussed as possible explanations for the observed noncorrelations. In addition, however, it is proposed to pay attention to specific mechanisms such as receptor mediated cellular effects which are not related to the generation of electrophiles. The effects of trans-4-aminostilbene and 2-amino-fluorene derivatives on rat liver are compared. It is concluded that trans-4-acetylamino-stilbene is a strong liver tumor initiator but an incomplete liver carcinogen lacking tumor promoting properties, and that 2-acetylaminofluorene is a complete liver carcinogen with initiating and promoting properties.
许多研究结果支持这样一种观点，即芳香胺生成DNA加合物与致癌作用存在因果关系。在大多数情况下都已鉴定出加合物，并对代表性实例进行了综述。然而，DNA加合物的程度和持久性（DNA剂量）与不同组织的肿瘤反应之间的相关性并不令人满意。DNA损伤、修复、间接和继发性DNA损伤的分布被讨论为观察到的不相关性的可能解释。此外，还建议关注特定机制，如与亲电试剂生成无关的受体介导的细胞效应。比较了反式-4-氨基芪和2-氨基芴衍生物对大鼠肝脏的影响。得出的结论是，反式-4-乙酰氨基芪是一种强烈的肝肿瘤引发剂，但却是一种缺乏肿瘤促进特性的不完全肝致癌物，而2-乙酰氨基芴是一种具有引发和促进特性的完全肝致癌物。
