Quinn T C, Taylor H R, Schachter J
J Infect Dis. 1986 Nov;154(5):833-41. doi: 10.1093/infdis/154.5.833.
To serially examine the immunopathogenesis and histopathology of rectal infection with Chlamydia trachomatis, we inoculated five cynomolgus monkeys with C. trachomatis serovar E (non-LGV) and five with serovar L2 (LGV). After inoculation, C. trachomatis was isolated from rectal cultures in three of five non-LGV-infected monkeys and in all five LGV-infected monkeys for a period of 10 weeks. LGV-infected monkeys developed a severe hemorrhagic ulcerative proctitis, in contrast to a mild proctitis in the non-LGV-infected monkeys. Hyperplasia of lymphoid follicles and a mucosal polymorphonuclear leukocyte and mononuclear cell infiltrate were evident in all infected monkeys. Crypt abscesses with giant cells and a rare granuloma formation were present in two of five LGV-infected monkeys. C. trachomatis inclusions were initially present in epithelial cells and later in tissue histiocytes. Experimental primate infection with C. trachomatis appears to clinically and histopathologically mimic rectal infection in humans and provides a model for immunopathogenesis studies in chlamydial proctitis and granulomatous proctitis.
为了连续观察沙眼衣原体直肠感染的免疫发病机制和组织病理学变化，我们给5只食蟹猴接种了沙眼衣原体血清型E（非淋巴肉芽肿性），给另外5只接种了血清型L2（淋巴肉芽肿性）。接种后，在5只非淋巴肉芽肿性感染的猴子中有3只以及所有5只淋巴肉芽肿性感染的猴子的直肠培养物中分离出沙眼衣原体，持续了10周。与非淋巴肉芽肿性感染的猴子发生的轻度直肠炎不同，淋巴肉芽肿性感染的猴子出现了严重的出血性溃疡性直肠炎。所有感染的猴子均可见淋巴滤泡增生以及黏膜多形核白细胞和单核细胞浸润。5只淋巴肉芽肿性感染的猴子中有2只出现了伴有巨细胞的隐窝脓肿和罕见的肉芽肿形成。沙眼衣原体包涵体最初出现在上皮细胞中，随后出现在组织组织细胞中。食蟹猴实验性感染沙眼衣原体在临床和组织病理学上似乎模拟了人类的直肠感染，并为衣原体直肠炎和肉芽肿性直肠炎的免疫发病机制研究提供了一个模型。
