Orda R, Samra Z, Levy Y, Shperber Y, Scapa E
Department of Surgery A, Assaf Harofeh Medical Center, Zerifin, Israel.
J R Soc Med. 1990 Jan;83(1):15-7. doi: 10.1177/014107689008300108.
Serological tests of 35 patients suffering from inflammatory bowel disease were compared to those of 35 healthy controls. The tests were performed using the indirect immunoperoxidase assay. Ninety-three per cent of 15 patients with Crohn's disease had IgG antibodies against Chlamydia, compared to 26% in the control group. In the 20 patients with ulcerative colitis, 45% had IgG antibodies against Chlamydia, compared to 10% in the control group. High serum titres of IgG antibodies were found in most of the patients with inflammatory bowel disease, mainly with Crohn's disease, while weak reactions appeared in most of the controls in which antibodies were detected. These results suggest a high incidence of Chlamydia infection in the studied patients with inflammatory bowel disease, especially in those with Crohn's disease. The possible association between Chlamydia trachomatis and inflammatory bowel disease is discussed.
对35例炎症性肠病患者的血清学检测结果与35名健康对照者进行了比较。检测采用间接免疫过氧化物酶测定法。15例克罗恩病患者中，93%有抗衣原体IgG抗体，而对照组为26%。20例溃疡性结肠炎患者中，45%有抗衣原体IgG抗体，对照组为10%。大多数炎症性肠病患者，主要是克罗恩病患者，血清中IgG抗体滴度较高，而在检测出抗体的大多数对照者中反应较弱。这些结果表明，在研究的炎症性肠病患者中，衣原体感染的发生率较高，尤其是克罗恩病患者。文中讨论了沙眼衣原体与炎症性肠病之间可能的关联。
