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[无症状性颈动脉狭窄的神经学风险评估及0期颈动脉手术价值的探讨。基于一项对123例闭塞性病变的研究]

[Evaluation of the neurological risk of asymptomatic carotid stenosis and discussion of the value of carotid surgery in stage 0. Apropos of a study of 123 obliterative lesions].

作者信息

Neveu P, Dubois-Pacque N, Piétri J

出版信息

J Mal Vasc. 1986;11(3):277-81.

PMID:3534129
Abstract

The authors analyzed neurological risk on the basis of the study of 123 asymptomatic obstructive carotid lesions. Patients were divided into two groups: Group A (54 patients undergoing prophylactic endarterectomy). Group B (69 patients not undergoing surgery). Definition of the carotid lesion was based upon a combination of Doppler, sonography and arteriography results. Assessment of comparative neurological risk, on the basis of a hemodynamic definition of the stenosis, in the two patient groups, led to definition of appropriate management of an asymptomatic carotid stenosis. In group A, operative mortality was nil and there was one transient ischemic accident. In group B, there were 12 accidents, 9 transient and 3 permanent. In this latter group there was one neurological death, i. e. mortality of neurological origin of 1.5%. Evaluation of risk initially requires definition of the stenosis. The presence of a carotid bruit alone is inadequate. Doppler and sonography, followed where necessary by arteriography, define the degree of stenosis which is the primordial prognostic feature. The difference of risk between a population undergoing surgery or not is statistically significant, in particular in hemodynamically tight stenosis. Finally, the degree of stenosis influences the severity of any subsequent accident, although this has not been proved statistically. In the majority of cases, the initial accident would appear to be regressive. In total, 4 concepts have been defined: the risk of carotid surgery at stage 0 is low, being of the order of 0. Overall neurological risk is less in the long term in asymptomatic patients who have undergone surgery than in those who have not been operated upon.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

作者基于对123例无症状性阻塞性颈动脉病变的研究分析了神经学风险。患者被分为两组:A组(54例接受预防性动脉内膜切除术),B组(69例未接受手术)。颈动脉病变的定义基于多普勒、超声检查和动脉造影结果的综合判断。根据狭窄的血流动力学定义对两组患者的相对神经学风险进行评估,从而确定无症状性颈动脉狭窄的适当治疗方法。A组手术死亡率为零,有1例短暂性缺血发作。B组有12次发作,9次短暂性发作,3次永久性发作。在后一组中有1例神经学死亡,即神经源性死亡率为1.5%。风险评估首先需要确定狭窄情况。仅凭颈动脉杂音是不够的。多普勒和超声检查,必要时辅以动脉造影,可确定狭窄程度,这是主要的预后特征。手术组和非手术组人群的风险差异具有统计学意义,尤其是在血流动力学严重狭窄的情况下。最后,狭窄程度会影响任何后续发作的严重程度,尽管这在统计学上尚未得到证实。在大多数情况下,最初的发作似乎会自行消退。总共定义了4个概念:0期颈动脉手术风险较低,约为0。从长期来看,接受手术的无症状患者的总体神经学风险低于未接受手术的患者。(摘要截选至250字)

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