Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China; Binzhou Medical University, Yantai, Shandong, PR China.
Department of Radiology, Central Hospital of Dongying District, Dongying, Shandong, PR China.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102830. doi: 10.1016/j.pdpdt.2022.102830. Epub 2022 Mar 25.
Cancer remains a health-related concern globally. The application of light to be used as therapeuticagent including cancer has been used for several thousand years. Photodynamic therapy (PDT) is a modern, non-invasive therapeutic modality for the treatment of various cancers and infections by bacteria, fungi, and viruses. Mitochondria are subcellular, double-membrane organelles that have a role in cancer and anticancer therapy. Mitochondria play a key role in regulation of apoptosis and these organelles produce most of the cell's energy which enhance its targeting objective. The role of mitochondria in anticancer approach is achieved by targeting its metabolism (glycolysis and TCA cycle) and apoptotic and ROS homeostasis. The role of mitochondria-targeted cancer therapies in photodynamic therapy have proven to be more effective than other similar non-targeting techniques. Particularly in PDT, mitochondria-targeting sensitizers are important as they have a crucial role in overcoming the hypoxia factor, resulting in high efficacy. IR-730 and IR-Pyr are the indocyine derivatives photosensitizers that play a crucial role in targeting mitochondria because of their better photostability during laser irradiation. Clinical and pre-clinical trials are going on this approach to target different solid tumors using mitochondrial targeted photodynamic therapy.
癌症仍然是全球关注的健康问题。几千年来，光已被应用于治疗疾病，包括癌症。光动力疗法（PDT）是一种治疗各种癌症以及细菌、真菌和病毒感染的现代非侵入性治疗方法。线粒体是亚细胞的双层膜细胞器，在癌症和抗癌治疗中发挥作用。线粒体在调节细胞凋亡中起着关键作用，这些细胞器产生细胞的大部分能量，从而增强其靶向目标。线粒体在抗癌方法中的作用是通过靶向其代谢（糖酵解和 TCA 循环）、凋亡和 ROS 平衡来实现的。与其他类似的非靶向技术相比，靶向线粒体的癌症疗法在光动力疗法中的应用已被证明更为有效。特别是在 PDT 中，线粒体靶向敏化剂非常重要，因为它们在克服缺氧因素方面起着关键作用，从而提高了疗效。IR-730 和 IR-Pyr 是吲哚菁染料类光敏剂，由于在激光照射期间具有更好的光稳定性，因此在靶向线粒体方面起着至关重要的作用。正在进行临床和临床前试验，以使用线粒体靶向光动力疗法针对不同的实体瘤。
